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Page 1
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. Shibata A, et al. Among authors: moiani d. Mol Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Epub 2013 Dec 5. Mol Cell. 2014. PMID: 24316220 Free PMC article.
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.
Das D, Moiani D, Axelrod HL, Miller MD, McMullan D, Jin KK, Abdubek P, Astakhova T, Burra P, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Ernst D, Feuerhelm J, Grant JC, Grzechnik A, Grzechnik SK, Han GW, Jaroszewski L, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Weekes D, Xu Q, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tainer JA, Wilson IA. Das D, et al. Among authors: moiani d. J Mol Biol. 2010 Apr 2;397(3):647-63. doi: 10.1016/j.jmb.2010.01.049. Epub 2010 Feb 1. J Mol Biol. 2010. PMID: 20122942 Free PMC article.
RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.
Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini-Denchi E, Boddy MN. Groocock LM, et al. Among authors: moiani d. EMBO Rep. 2014 May;15(5):601-8. doi: 10.1002/embr.201338369. Epub 2014 Apr 8. EMBO Rep. 2014. PMID: 24714598 Free PMC article.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Houl JH, et al. Among authors: moiani d. Nat Commun. 2019 Dec 11;10(1):5654. doi: 10.1038/s41467-019-13508-4. Nat Commun. 2019. PMID: 31827085 Free PMC article.
24 results