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Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism.
Fournier B, Murray B, Gutzwiller S, Marcaletti S, Marcellin D, Bergling S, Brachat S, Persohn E, Pierrel E, Bombard F, Hatakeyama S, Trendelenburg AU, Morvan F, Richardson B, Glass DJ, Lach-Trifilieff E, Feige JN. Fournier B, et al. Among authors: hatakeyama s. Mol Cell Biol. 2012 Jul;32(14):2871-9. doi: 10.1128/MCB.06575-11. Epub 2012 May 14. Mol Cell Biol. 2012. PMID: 22586266 Free PMC article.
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.
Pettersen K, Andersen S, van der Veen A, Nonstad U, Hatakeyama S, Lambert C, Lach-Trifilieff E, Moestue S, Kim J, Grønberg BH, Schilb A, Jacobi C, Bjørkøy G. Pettersen K, et al. Among authors: hatakeyama s. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):195-207. doi: 10.1002/jcsm.12489. Epub 2019 Aug 21. J Cachexia Sarcopenia Muscle. 2020. PMID: 31436048 Free PMC article.
Therapeutic potential of muscle growth promoters in a stress urinary incontinence model.
Yang J, Balog B, Deng K, Hanzlicek B, Rietsch A, Kuang M, Hatakeyama S, Lach-Trifilieff E, Zhu H, Damaser MS. Yang J, et al. Among authors: hatakeyama s. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F436-F446. doi: 10.1152/ajprenal.00122.2020. Epub 2020 Jul 20. Am J Physiol Renal Physiol. 2020. PMID: 32686522 Free article.
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.
Koziczak-Holbro M, Rigel DF, Dumotier B, Sykes DA, Tsao J, Nguyen NH, Bösch J, Jourdain M, Flotte L, Adachi Y, Kiffe M, Azria M, Fairhurst RA, Charlton SJ, Richardson BP, Lach-Trifilieff E, Glass DJ, Ullrich T, Hatakeyama S. Koziczak-Holbro M, et al. Among authors: hatakeyama s. J Pharmacol Exp Ther. 2019 May;369(2):188-199. doi: 10.1124/jpet.118.255307. Epub 2019 Feb 28. J Pharmacol Exp Ther. 2019. PMID: 30819762
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.
Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Segatto M, et al. Among authors: hatakeyama s. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. Nat Commun. 2017. PMID: 29167426 Free PMC article.
1,109 results