Lin R - Search Results

1

Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites.

Lin R, Weaner LE, Hoerr DC, Salter R, Gong Y. Lin R, et al. J Labelled Comp Radiopharm. 2013 Jan;56(1):22-6. doi: 10.1002/jlcr.3013. Epub 2013 Jan 10. J Labelled Comp Radiopharm. 2013. PMID: 24285137

2

Syntheses of isotope-labeled SGLT2 inhibitor canagliflozin (JNJ-28431754).

Lin R, Hoerr DC, Weaner LE, Salter R. Lin R, et al. J Labelled Comp Radiopharm. 2017 Nov;60(13):616-623. doi: 10.1002/jlcr.3542. Epub 2017 Sep 18. J Labelled Comp Radiopharm. 2017. PMID: 28833358

3

Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)_n ) and [1-¹⁴ C]-CA (PEG)_n via oxa-Michael addition of amino-polyethylene glycols to propiolates vs to acrylates.

Song F, Chen L, Lin R, Salter R. Song F, et al. Among authors: lin r. J Labelled Comp Radiopharm. 2020 Jan;63(1):15-24. doi: 10.1002/jlcr.3816. Epub 2019 Dec 13. J Labelled Comp Radiopharm. 2020. PMID: 31736118

4

Synthesis of deuterium-labeled CCR2 antagonist JNJ-26131300, [4-(1H-indol- 3-yl)-piperidin-1-yl]-{1-[3-(3,4,5-trifluoro-phenyl)-acryloyl]-piperidin-4-yl}-acetic acid.

Lin R, Gong Y, Salter R. Lin R, et al. J Labelled Comp Radiopharm. 2022 May 15;65(5):147-151. doi: 10.1002/jlcr.3967. Epub 2022 Mar 8. J Labelled Comp Radiopharm. 2022. PMID: 35218060

5

Nitro-Activated Nucleobase Exchange in the Synthesis of 2'-Fluoro-2'-Deoxyribonucleosides.

Gong Y, Zhang W, Chen L, Lin R, Zhou R, Salter R. Gong Y, et al. Among authors: lin r. J Org Chem. 2022 Jul 15;87(14):9330-9342. doi: 10.1021/acs.joc.2c01093. Epub 2022 Jun 27. J Org Chem. 2022. PMID: 35759615

6

Hydroxylation of Substituted Anilides with Metallaphotocatalysis.

Khatri BB, Chen L, Xu D, Salter R, Lin R. Khatri BB, et al. Among authors: lin r. ACS Omega. 2024 Apr 24;9(18):19982-19991. doi: 10.1021/acsomega.3c10008. eCollection 2024 May 7. ACS Omega. 2024. PMID: 38737023 Free PMC article.

7

Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.

Huang S, Connolly PJ, Lin R, Emanuel S, Middleton SA. Huang S, et al. Among authors: lin r. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. doi: 10.1016/j.bmcl.2006.04.071. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682186

8

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Among authors: lin r. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

9

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Lin R, Johnson SG, Connolly PJ, Wetter SK, Binnun E, Hughes TV, Murray WV, Pandey NB, Moreno-Mazza SJ, Adams M, Fuentes-Pesquera AR, Middleton SA. Lin R, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2333-7. doi: 10.1016/j.bmcl.2009.02.067. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19286381

10

The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.

Emanuel S, Rugg CA, Gruninger RH, Lin R, Fuentes-Pesquera A, Connolly PJ, Wetter SK, Hollister B, Kruger WW, Napier C, Jolliffe L, Middleton SA. Emanuel S, et al. Among authors: lin r. Cancer Res. 2005 Oct 1;65(19):9038-46. doi: 10.1158/0008-5472.CAN-05-0882. Cancer Res. 2005. PMID: 16204078

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