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The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors.
Dihal AA, Boot A, van Roon EH, Schrumpf M, Fariña-Sarasqueta A, Fiocco M, Zeestraten EC, Kuppen PJ, Morreau H, van Wezel T, Boer JM. Dihal AA, et al. Among authors: van roon eh. PLoS One. 2013 Nov 7;8(11):e79898. doi: 10.1371/journal.pone.0079898. eCollection 2013. PLoS One. 2013. PMID: 24244575 Free PMC article.
Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
van Roon EH, van Puijenbroek M, Middeldorp A, van Eijk R, de Meijer EJ, Erasmus D, Wouters KA, van Engeland M, Oosting J, Hes FJ, Tops CM, van Wezel T, Boer JM, Morreau H. van Roon EH, et al. Among authors: van puijenbroek m, van eijk r, van wezel t, van engeland m. BMC Cancer. 2010 May 5;10:180. doi: 10.1186/1471-2407-10-180. BMC Cancer. 2010. PMID: 20444249 Free PMC article.
Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options.
Stumpel DJ, Schneider P, van Roon EH, Boer JM, de Lorenzo P, Valsecchi MG, de Menezes RX, Pieters R, Stam RW. Stumpel DJ, et al. Among authors: van roon eh. Blood. 2009 Dec 24;114(27):5490-8. doi: 10.1182/blood-2009-06-227660. Epub 2009 Oct 23. Blood. 2009. PMID: 19855078 Free article.
The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.
Garrido Castro P, van Roon EHJ, Pinhanços SS, Trentin L, Schneider P, Kerstjens M, Te Kronnie G, Heidenreich O, Pieters R, Stam RW. Garrido Castro P, et al. Among authors: van roon ehj. Leukemia. 2018 Feb;32(2):323-331. doi: 10.1038/leu.2017.216. Epub 2017 Jul 10. Leukemia. 2018. PMID: 28690313
15 results