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The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF. Haas DA, et al. Among authors: santag s. PLoS Pathog. 2013;9(11):e1003737. doi: 10.1371/journal.ppat.1003737. Epub 2013 Nov 7. PLoS Pathog. 2013. PMID: 24244164 Free PMC article. Clinical Trial.
Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency.
Mariggiò G, Koch S, Zhang G, Weidner-Glunde M, Rückert J, Kati S, Santag S, Schulz TF. Mariggiò G, et al. Among authors: santag s. PLoS Pathog. 2017 Apr 21;13(4):e1006335. doi: 10.1371/journal.ppat.1006335. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28430817 Free PMC article.
An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo.
Dubich T, Lieske A, Santag S, Beauclair G, Rückert J, Herrmann J, Gorges J, Büsche G, Kazmaier U, Hauser H, Stadler M, Schulz TF, Wirth D. Dubich T, et al. Among authors: santag s. J Mol Med (Berl). 2019 Mar;97(3):311-324. doi: 10.1007/s00109-018-01733-1. Epub 2019 Jan 4. J Mol Med (Berl). 2019. PMID: 30610257
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.
Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Alkharsah KR, et al. Among authors: santag s. J Virol. 2011 Oct;85(19):10375-88. doi: 10.1128/JVI.00226-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795355 Free PMC article.