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Stabilization of G protein-coupled receptors by point mutations.
Heydenreich FM, Vuckovic Z, Matkovic M, Veprintsev DB. Heydenreich FM, et al. Among authors: veprintsev db. Front Pharmacol. 2015 Apr 20;6:82. doi: 10.3389/fphar.2015.00082. eCollection 2015. Front Pharmacol. 2015. PMID: 25941489 Free PMC article. Review.
Universal allosteric mechanism for Gα activation by GPCRs.
Flock T, Ravarani CNJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate CG, Veprintsev DB, Babu MM. Flock T, et al. Among authors: veprintsev db. Nature. 2015 Aug 13;524(7564):173-179. doi: 10.1038/nature14663. Epub 2015 Jul 6. Nature. 2015. PMID: 26147082 Free PMC article.
Probing Gαi1 protein activation at single-amino acid resolution.
Sun D, Flock T, Deupi X, Maeda S, Matkovic M, Mendieta S, Mayer D, Dawson R, Schertler GFX, Madan Babu M, Veprintsev DB. Sun D, et al. Among authors: veprintsev db. Nat Struct Mol Biol. 2015 Sep;22(9):686-694. doi: 10.1038/nsmb.3070. Epub 2015 Aug 10. Nat Struct Mol Biol. 2015. PMID: 26258638 Free PMC article.
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.
Venkatakrishnan AJ, Deupi X, Lebon G, Heydenreich FM, Flock T, Miljus T, Balaji S, Bouvier M, Veprintsev DB, Tate CG, Schertler GF, Babu MM. Venkatakrishnan AJ, et al. Among authors: veprintsev db. Nature. 2016 Aug 25;536(7617):484-7. doi: 10.1038/nature19107. Epub 2016 Aug 15. Nature. 2016. PMID: 27525504 Free PMC article.
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.
Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M. Beautrait A, et al. Among authors: veprintsev db. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054. Nat Commun. 2017. PMID: 28416805 Free PMC article.
High-throughput mutagenesis using a two-fragment PCR approach.
Heydenreich FM, Miljuš T, Jaussi R, Benoit R, Milić D, Veprintsev DB. Heydenreich FM, et al. Among authors: veprintsev db. Sci Rep. 2017 Jul 28;7(1):6787. doi: 10.1038/s41598-017-07010-4. Sci Rep. 2017. PMID: 28754896 Free PMC article.
104 results