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2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors.
Fukunaga K, Uehara F, Aritomo K, Shoda A, Hiki S, Okuyama M, Usui Y, Watanabe K, Yamakoshi K, Kohara T, Hanano T, Tanaka H, Tsuchiya S, Sunada S, Saito K, Eguchi J, Yuki S, Asano S, Tanaka S, Mori A, Yamagami K, Baba H, Horikawa T, Fujimura M. Fukunaga K, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7. doi: 10.1016/j.bmcl.2013.09.020. Epub 2013 Sep 21. Bioorg Med Chem Lett. 2013. PMID: 24176395
6-(4-Pyridyl)pyrimidin-4(3H)-ones as CNS penetrant glycogen synthase kinase-3β inhibitors.
Uehara F, Shoda A, Aritomo K, Fukunaga K, Watanabe K, Ando R, Shinoda M, Ueno H, Kubodera H, Sunada S, Saito K, Kaji T, Asano S, Eguchi J, Yuki S, Tanaka S, Yoneyama Y, Niwa T. Uehara F, et al. Among authors: fukunaga k. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6928-32. doi: 10.1016/j.bmcl.2013.09.021. Epub 2013 Sep 17. Bioorg Med Chem Lett. 2013. PMID: 24094818
Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease.
Fukunaga K, Sakai D, Watanabe K, Nakayama K, Kohara T, Tanaka H, Sunada S, Nabeno M, Okamoto M, Saito K, Eguchi J, Mori A, Tanaka S, Inazawa K, Horikawa T. Fukunaga K, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1086-91. doi: 10.1016/j.bmcl.2015.01.005. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25655721
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Kohara T, Nakayama K, Watanabe K, Kusaka SI, Sakai D, Tanaka H, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Mori A, Tanaka S, Bessho T, Takiguchi-Hayashi K, Horikawa T. Kohara T, et al. Among authors: fukunaga k. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3733-3738. doi: 10.1016/j.bmcl.2017.06.077. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712706
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Usui Y, Uehara F, Hiki S, Watanabe K, Tanaka H, Shouda A, Yokoshima S, Aritomo K, Adachi T, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Yamagami K, Asano S, Tanaka S, Yuki S, Yoshii N, Fujimura M, Horikawa T. Usui Y, et al. Among authors: fukunaga k. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3726-3732. doi: 10.1016/j.bmcl.2017.06.078. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712708
Blood DNA virome associates with autoimmune diseases and COVID-19.
Sasa N, Kojima S, Koide R, Hasegawa T, Namkoong H, Hirota T, Watanabe R, Nakamura Y, Oguro-Igashira E, Ogawa K, Yata T, Sonehara K, Yamamoto K, Kishikawa T, Sakaue S, Edahiro R, Shirai Y, Maeda Y, Nii T, Chubachi S, Tanaka H, Yabukami H, Suzuki A, Nakajima K, Arase N, Okamoto T, Nishikawa R, Namba S, Naito T, Miyagawa I, Tanaka H, Ueno M, Ishitsuka Y, Furuta J, Kunimoto K, Kajihara I, Fukushima S, Miyachi H, Matsue H, Kamata M, Momose M, Bito T, Nagai H, Ikeda T, Horikawa T, Adachi A, Matsubara T, Ikumi K, Nishida E, Nakagawa I, Yagita-Sakamaki M, Yoshimura M, Ohshima S, Kinoshita M, Ito S, Arai T, Hirose M, Tanino Y, Nikaido T, Ichiwata T, Ohkouchi S, Hirano T, Takada T, Tazawa R, Morimoto K, Takaki M, Konno S, Suzuki M, Tomii K, Nakagawa A, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Uchida A, Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Saigusa M, Shirai T, Hizawa N, Nakata K; Japan COVID-19 Task Force; Imafuku S, Tada Y, Asano Y, Sato S, Nishigori C, Jinnin M, Ihn H, Asahina A, Saeki H, Kawamura T, Shimada S, Katayama I, Poisner HM, Mack TM, Bick AG, Higasa K, Okuno T, Mochizuki H, Ishii M, Koike R, K… See abstract for full author list ➔ Sasa N, et al. Among authors: fukunaga k. Nat Genet. 2025 Jan 3. doi: 10.1038/s41588-024-02022-z. Online ahead of print. Nat Genet. 2025. PMID: 39753770
Efficacy of imeglimin in patients with type 2 diabetes mellitus complicated by metabolic dysfunction-associated steatotic liver disease: A multicentre study.
Fukunaga K, Morishita A, Imachi H, Oura K, Sato S, Kobayashi T, Saheki T, Yoshimura T, Komori K, Nakahara M, Tadokoro T, Fujita K, Tani J, Kobara H, Murao K. Fukunaga K, et al. Diabetes Obes Metab. 2024 Dec 26. doi: 10.1111/dom.16157. Online ahead of print. Diabetes Obes Metab. 2024. PMID: 39726210
Long COVID among the first three waves of COVID-19 in Japan: a multicentre cohort study.
Takaoka H, Kawada I, Hiruma G, Nagashima K, Terai H, Ishida N, Namkoong H, Asakura T, Masaki K, Miyata J, Chubachi S, Ohgino K, Otsuka K, Miyao N, Odani T, Watase M, Baba R, Okamori S, Arai D, Nakachi I, Kuwahara N, Fujiwara A, Okada T, Ishiguro T, Isono T, Ishii M, Sato Y, Fukunaga K. Takaoka H, et al. Among authors: fukunaga k. BMJ Open Respir Res. 2024 Dec 25;11(1):e002137. doi: 10.1136/bmjresp-2023-002137. BMJ Open Respir Res. 2024. PMID: 39721744 Free PMC article.
The relationship between long COVID, labor productivity, and socioeconomic losses in Japan: A cohort study.
Konishi S, Masaki K, Shimamoto K, Ibuka Y, Goto R, Namkoong H, Chubachi S, Terai H, Asakura T, Miyata J, Azekawa S, Nakagawara K, Tanaka H, Morita A, Harada N, Sasano H, Nakamura A, Kusaka Y, Ohba T, Nakano Y, Nishio K, Nakajima Y, Suzuki S, Yoshida S, Tateno H, Fukunaga K. Konishi S, et al. Among authors: fukunaga k. IJID Reg. 2024 Nov 20;14:100495. doi: 10.1016/j.ijregi.2024.100495. eCollection 2025 Mar. IJID Reg. 2024. PMID: 39717862 Free PMC article.
Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia.
Tanaka H, Kamata H, Ishii M, Asakura T, Namkoong H, Nakagawara K, Morita A, Kusumoto T, Azekawa S, Kaji M, Nagao G, Fukunaga N, Nishimura T, Asakura K, Hasegawa N, Fukunaga K. Tanaka H, et al. Among authors: fukunaga k. Am J Respir Cell Mol Biol. 2024 Dec 19. doi: 10.1165/rcmb.2024-0276OC. Online ahead of print. Am J Respir Cell Mol Biol. 2024. PMID: 39700516
1,414 results