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Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Nachtergaele S, et al. Among authors: mydock lk. Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765. Nat Chem Biol. 2012. PMID: 22231273 Free PMC article.
Concise Synthesis of the Unnatural Sphingosine and Psychosine Enantiomer.
Parameswar AR, Hawkins JA, Mydock LK, Sands MS, Demchenko AV. Parameswar AR, et al. Among authors: mydock lk. European J Org Chem. 2010 Jun;2010(17):10.1002/ejoc.201000024. doi: 10.1002/ejoc.201000024. European J Org Chem. 2010. PMID: 24371429 Free PMC article.