Herbert TP - Search Results

1

ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.

Omikorede O, Qi C, Gorman T, Chapman P, Yu A, Smith DM, Herbert TP. Omikorede O, et al. Among authors: herbert tp. Nutr Diabetes. 2013 Oct 21;3(10):e93. doi: 10.1038/nutd.2013.35. Nutr Diabetes. 2013. PMID: 24145577 Free PMC article.

2

PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.

Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP. Moore CE, et al. Among authors: herbert tp. Mol Endocrinol. 2011 Feb;25(2):315-26. doi: 10.1210/me.2010-0309. Epub 2010 Dec 30. Mol Endocrinol. 2011. PMID: 21193559 Free PMC article.

3

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1.

Xie J, El Sayed NM, Qi C, Zhao X, Moore CE, Herbert TP. Xie J, et al. Among authors: herbert tp. J Mol Endocrinol. 2014 Aug;53(1):105-15. doi: 10.1530/JME-13-0200. J Mol Endocrinol. 2014. PMID: 24994913

4

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.

Xie J, Herbert TP. Xie J, et al. Among authors: herbert tp. Cell Mol Life Sci. 2012 Apr;69(8):1289-304. doi: 10.1007/s00018-011-0874-4. Epub 2011 Nov 9. Cell Mol Life Sci. 2012. PMID: 22068611 Free PMC article. Review.

5

The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells.

Chan SMH, Zhao X, Elfowiris A, Ratnam C, Herbert TP. Chan SMH, et al. Among authors: herbert tp. Biochimie. 2017 Jul;138:156-167. doi: 10.1016/j.biochi.2017.04.018. Epub 2017 May 4. Biochimie. 2017. PMID: 28478109 Free article.

6

Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

Barlow AD, Nicholson ML, Herbert TP. Barlow AD, et al. Among authors: herbert tp. Diabetes. 2013 Aug;62(8):2674-82. doi: 10.2337/db13-0106. Diabetes. 2013. PMID: 23881200 Free PMC article. Review.

7

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).

Barlow AD, Xie J, Moore CE, Campbell SC, Shaw JA, Nicholson ML, Herbert TP. Barlow AD, et al. Among authors: herbert tp. Diabetologia. 2012 May;55(5):1355-65. doi: 10.1007/s00125-012-2475-7. Diabetologia. 2012. PMID: 22314813 Free PMC article.

8

PERK in the life and death of the pancreatic beta-cell.

Herbert TP. Herbert TP. Biochem Soc Trans. 2007 Nov;35(Pt 5):1205-7. doi: 10.1042/BST0351205. Biochem Soc Trans. 2007. PMID: 17956313 Review.

9

Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.

Chan SMH, Lau YS, Miller AA, Ku JM, Potocnik S, Ye JM, Woodman OL, Herbert TP. Chan SMH, et al. Among authors: herbert tp. Endocrinology. 2017 Oct 1;158(10):3162-3173. doi: 10.1210/en.2016-1879. Endocrinology. 2017. PMID: 28938442 Free article.

10

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.

Johnson CE, Hunt DK, Wiltshire M, Herbert TP, Sampson JR, Errington RJ, Davies DM, Tee AR. Johnson CE, et al. Among authors: herbert tp. Mol Oncol. 2015 Mar;9(3):675-88. doi: 10.1016/j.molonc.2014.11.005. Epub 2014 Nov 22. Mol Oncol. 2015. PMID: 25498902 Free PMC article.

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