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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses.
J Pharmacol Exp Ther. 2014 Jan;348(1):96-105. doi: 10.1124/jpet.113.207878. Epub 2013 Oct 16.
J Pharmacol Exp Ther. 2014.
PMID: 24133297
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A, Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB.
Lanford RE, et al. Among authors: fosdick a.
Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10. doi: 10.1053/j.gastro.2013.02.003. Epub 2013 Feb 13.
Gastroenterology. 2013.
PMID: 23415804
Free PMC article.
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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
Menne S, Tumas DB, Liu KH, Thampi L, AlDeghaither D, Baldwin BH, Bellezza CA, Cote PJ, Zheng J, Halcomb R, Fosdick A, Fletcher SP, Daffis S, Li L, Yue P, Wolfgang GH, Tennant BC.
Menne S, et al. Among authors: fosdick a.
J Hepatol. 2015 Jun;62(6):1237-45. doi: 10.1016/j.jhep.2014.12.026. Epub 2015 Jan 2.
J Hepatol. 2015.
PMID: 25559326
Free PMC article.
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Assessment of two external telemetry systems (PhysioJacket and JET) in beagle dogs with telemetry implants.
Chui RW, Fosdick A, Conner R, Jiang J, Bruenner BA, Vargas HM.
Chui RW, et al. Among authors: fosdick a.
J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):58-68. doi: 10.1016/j.vascn.2009.04.196. Epub 2009 May 5.
J Pharmacol Toxicol Methods. 2009.
PMID: 19426820
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