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Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.
Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. Büttner S, et al. Among authors: macchi f. EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15. EMBO J. 2013. PMID: 24129513 Free PMC article.
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.
Van der Perren A, Macchi F, Toelen J, Carlon MS, Maris M, de Loor H, Kuypers DR, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Van der Perren A, et al. Among authors: macchi f. Neurobiol Aging. 2015 Mar;36(3):1559-68. doi: 10.1016/j.neurobiolaging.2015.01.014. Epub 2015 Jan 21. Neurobiol Aging. 2015. PMID: 25660193 Free article.
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.
Oliveras-Salvá M, Macchi F, Coessens V, Deleersnijder A, Gérard M, Van der Perren A, Van den Haute C, Baekelandt V. Oliveras-Salvá M, et al. Among authors: macchi f. Neurobiol Aging. 2014 Nov;35(11):2625-2636. doi: 10.1016/j.neurobiolaging.2014.04.032. Epub 2014 Jun 14. Neurobiol Aging. 2014. PMID: 25037286
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Van der Perren A, et al. Among authors: macchi f. Neurobiol Aging. 2015 Mar;36(3):1543-58. doi: 10.1016/j.neurobiolaging.2014.11.015. Epub 2014 Dec 17. Neurobiol Aging. 2015. PMID: 25599874
Wildtype and A30P mutant alpha-synuclein form different fibril structures.
Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Svane AS, Manno M, Christiansen G, Nielsen NC, Oddershede L, Vestergaard B, Otzen DE. Nielsen SB, et al. Among authors: macchi f. PLoS One. 2013 Jul 4;8(7):e67713. doi: 10.1371/journal.pone.0067713. Print 2013. PLoS One. 2013. PMID: 23861789 Free PMC article.
The effect of osmolytes on protein fibrillation.
Macchi F, Eisenkolb M, Kiefer H, Otzen DE. Macchi F, et al. Int J Mol Sci. 2012;13(3):3801-3819. doi: 10.3390/ijms13033801. Epub 2012 Mar 21. Int J Mol Sci. 2012. PMID: 22489184 Free PMC article.
87 results