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Page 1
Preclinical characterization of GSK2336805, a novel inhibitor of hepatitis C virus replication that selects for resistance in NS5A.
Walker J, Crosby R, Wang A, Woldu E, Vamathevan J, Voitenleitner C, You S, Remlinger K, Duan M, Kazmierski W, Hamatake R. Walker J, et al. Among authors: vamathevan j. Antimicrob Agents Chemother. 2014;58(1):38-47. doi: 10.1128/AAC.01363-13. Epub 2013 Oct 14. Antimicrob Agents Chemother. 2014. PMID: 24126581 Free PMC article.
In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
Voitenleitner C, Crosby R, Walker J, Remlinger K, Vamathevan J, Wang A, You S, Johnson J 3rd, Woldu E, Van Horn S, Horton J, Creech K, Shotwell JB, Hong Z, Hamatake R. Voitenleitner C, et al. Among authors: vamathevan j. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24. doi: 10.1128/AAC.00874-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2013. PMID: 23939896 Free PMC article.
Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein.
Pouliot JJ, Thomson M, Xie M, Horton J, Johnson J, Krull D, Mathis A, Morikawa Y, Parks D, Peterson R, Shimada T, Thomas E, Vamathevan J, Van Horn S, Xiong Z, Hamatake R, Peat AJ. Pouliot JJ, et al. Among authors: vamathevan j. Antimicrob Agents Chemother. 2015 Oct;59(10):6539-50. doi: 10.1128/AAC.00813-15. Epub 2015 Aug 10. Antimicrob Agents Chemother. 2015. PMID: 26259798 Free PMC article.
Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.
Grimley R, Polyakova O, Vamathevan J, McKenary J, Hayes B, Patel C, Smith J, Bridges A, Fosberry A, Bhardwaja A, Mouzon B, Chung CW, Barrett N, Richmond N, Modha S, Solari R. Grimley R, et al. Among authors: vamathevan j. PLoS One. 2012;7(7):e39847. doi: 10.1371/journal.pone.0039847. Epub 2012 Jul 6. PLoS One. 2012. PMID: 22792191 Free PMC article.
Identification of novel interacting partners of Sirtuin6.
Polyakova O, Borman S, Grimley R, Vamathevan J, Hayes B, Solari R. Polyakova O, et al. Among authors: vamathevan j. PLoS One. 2012;7(12):e51555. doi: 10.1371/journal.pone.0051555. Epub 2012 Dec 11. PLoS One. 2012. PMID: 23240041 Free PMC article.
Open Targets: a platform for therapeutic target identification and validation.
Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, Hasan S, Karamanis N, Maguire M, Papa E, Pierleoni A, Pignatelli M, Platt T, Rowland F, Wankar P, Bento AP, Burdett T, Fabregat A, Forbes S, Gaulton A, Gonzalez CY, Hermjakob H, Hersey A, Jupe S, Kafkas Ş, Keays M, Leroy C, Lopez FJ, Magarinos MP, Malone J, McEntyre J, Munoz-Pomer Fuentes A, O'Donovan C, Papatheodorou I, Parkinson H, Palka B, Paschall J, Petryszak R, Pratanwanich N, Sarntivijal S, Saunders G, Sidiropoulos K, Smith T, Sondka Z, Stegle O, Tang YA, Turner E, Vaughan B, Vrousgou O, Watkins X, Martin MJ, Sanseau P, Vamathevan J, Birney E, Barrett J, Dunham I. Koscielny G, et al. Among authors: vamathevan j. Nucleic Acids Res. 2017 Jan 4;45(D1):D985-D994. doi: 10.1093/nar/gkw1055. Epub 2016 Nov 29. Nucleic Acids Res. 2017. PMID: 27899665 Free PMC article.
28 results