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Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.
Zhang Y, Ikeno Y, Bokov A, Gelfond J, Jaramillo C, Zhang HM, Liu Y, Qi W, Hubbard G, Richardson A, Van Remmen H. Zhang Y, et al. Among authors: zhang hm. Free Radic Biol Med. 2013 Jul;60:300-6. doi: 10.1016/j.freeradbiomed.2013.02.026. Epub 2013 Feb 28. Free Radic Biol Med. 2013. PMID: 23459073 Free PMC article.
Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.
Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N. Zhang N, et al. Among authors: zhang y. Aging Cell. 2017 Aug;16(4):847-858. doi: 10.1111/acel.12613. Epub 2017 May 29. Aging Cell. 2017. PMID: 28556540 Free PMC article.
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H. Zhang Y, et al. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. doi: 10.1093/gerona/glp132. Epub 2009 Sep 23. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19776219 Free PMC article.
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