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Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions.
Grieger JC, Johnson JS, Gurda-Whitaker B, Agbandje-McKenna M, Samulski RJ. Grieger JC, et al. J Virol. 2007 Aug;81(15):7833-43. doi: 10.1128/JVI.00580-07. Epub 2007 May 16. J Virol. 2007. PMID: 17507473 Free PMC article.
In this study, the goal was to further examine the role of the unique Vp1 N terminus, the N terminus plus the recently identified nuclear localization signal (NLS) (J. C. Grieger, S. Snowdy, and R. J. Samulski, J. Virol 80:5199-5210, 2006), and the vir …
In this study, the goal was to further examine the role of the unique Vp1 N terminus, the N terminus plus the recently identified nuclear lo …
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
Bowles DE, McPhee SW, Li C, Gray SJ, Samulski JJ, Camp AS, Li J, Wang B, Monahan PE, Rabinowitz JE, Grieger JC, Govindasamy L, Agbandje-McKenna M, Xiao X, Samulski RJ. Bowles DE, et al. Among authors: grieger jc. Mol Ther. 2012 Feb;20(2):443-55. doi: 10.1038/mt.2011.237. Epub 2011 Nov 8. Mol Ther. 2012. PMID: 22068425 Free PMC article. Clinical Trial.
130 results