Nobuhara M - Search Results

1

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Funamoto S, et al. Among authors: nobuhara m. Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529. Nat Commun. 2013. PMID: 24108142 Free PMC article.

2

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. Kokawa A, et al. Among authors: nobuhara m. Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6. Acta Neuropathol Commun. 2015. PMID: 26531305 Free PMC article.

3

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.

Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Higashide H, et al. Among authors: nobuhara m. J Neurochem. 2017 Mar;140(6):955-962. doi: 10.1111/jnc.13942. Epub 2017 Jan 30. J Neurochem. 2017. PMID: 28032911 Free article.

4

Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.

Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S. Moniruzzaman M, et al. Among authors: nobuhara m. Biochem Biophys Res Commun. 2018 Jul 7;502(1):98-103. doi: 10.1016/j.bbrc.2018.05.126. Epub 2018 May 25. Biochem Biophys Res Commun. 2018. PMID: 29787759

5

Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.

Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Osawa S, et al. Among authors: nobuhara m. J Biol Chem. 2008 Jul 11;283(28):19283-92. doi: 10.1074/jbc.M705954200. Epub 2008 May 14. J Biol Chem. 2008. PMID: 18480063 Free article.

6

Quantitative fractionation of tissue microtubules with distinct biochemical properties reflecting their stability and lability.

Hagita A, Wada-Kakuda S, Nobuhara M, Kakuda N, Miyasaka T. Hagita A, et al. Among authors: nobuhara m. Biochem Biophys Res Commun. 2021 Jun 30;560:186-191. doi: 10.1016/j.bbrc.2021.04.117. Epub 2021 May 13. Biochem Biophys Res Commun. 2021. PMID: 33992960

7

Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.

Fujiwara H, Watanabe S, Iwata M, Ueda S, Nobuhara M, Wada-Kakuda S, Misonou H, Miyasaka T. Fujiwara H, et al. Among authors: nobuhara m. Biochem Biophys Res Commun. 2020 Jan 15;521(3):779-785. doi: 10.1016/j.bbrc.2019.10.191. Epub 2019 Nov 5. Biochem Biophys Res Commun. 2020. PMID: 31699369

8

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo.

Saito T, Chiku T, Oka M, Wada-Kakuda S, Nobuhara M, Oba T, Shinno K, Abe S, Asada A, Sumioka A, Takashima A, Miyasaka T, Ando K. Saito T, et al. Among authors: nobuhara m. Hum Mol Genet. 2021 Oct 13;30(21):1955-1967. doi: 10.1093/hmg/ddab162. Hum Mol Genet. 2021. PMID: 34137825 Free PMC article.

9

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

Ichinose M, Miki K, Tatematsu M, Furihata C, Nobuhara M, Ichihara Y, Tanji M, Sogawa K, Fujii-Kuriyama Y, Oka H, et al. Ichinose M, et al. Among authors: nobuhara m. Biochem Biophys Res Commun. 1988 Feb 29;151(1):275-82. doi: 10.1016/0006-291x(88)90590-6. Biochem Biophys Res Commun. 1988. PMID: 2831884

10

Expression and excretion of human pancreatic secretory trypsin inhibitor in lipoprotein-deletion mutant of Escherichia coli.

Kanamori T, Mizushima S, Shimizu Y, Morishita H, Kubota H, Nii A, Ogino H, Nagase Y, Kisaragi M, Nobuhara M. Kanamori T, et al. Among authors: nobuhara m. Gene. 1988 Jun 30;66(2):295-300. doi: 10.1016/0378-1119(88)90365-4. Gene. 1988. PMID: 3049250

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