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Page 1
Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function.
Saunders C, Siuta M, Robertson SD, Davis AR, Sauer J, Matthies HJG, Gresch PJ, Airey D, Lindsley CW, Schetz JA, Niswender KD, Veenstra-Vanderweele JM, Galli A. Saunders C, et al. Among authors: lindsley cw. Neurochem Int. 2014 Jul;73:113-121. doi: 10.1016/j.neuint.2013.09.015. Epub 2013 Sep 30. Neurochem Int. 2014. PMID: 24090638 Free PMC article.
Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.
Siuta MA, Robertson SD, Kocalis H, Saunders C, Gresch PJ, Khatri V, Shiota C, Kennedy JP, Lindsley CW, Daws LC, Polley DB, Veenstra-Vanderweele J, Stanwood GD, Magnuson MA, Niswender KD, Galli A. Siuta MA, et al. Among authors: lindsley cw. PLoS Biol. 2010 Jun 8;8(6):e1000393. doi: 10.1371/journal.pbio.1000393. PLoS Biol. 2010. PMID: 20543991 Free PMC article.
Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding.
Speed N, Saunders C, Davis AR, Owens WA, Matthies HJ, Saadat S, Kennedy JP, Vaughan RA, Neve RL, Lindsley CW, Russo SJ, Daws LC, Niswender KD, Galli A. Speed N, et al. Among authors: lindsley cw. PLoS One. 2011;6(9):e25169. doi: 10.1371/journal.pone.0025169. Epub 2011 Sep 28. PLoS One. 2011. PMID: 21969871 Free PMC article.
Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes.
Conrad KL, Davis AR, Silberman Y, Sheffler DJ, Shields AD, Saleh SA, Sen N, Matthies HJ, Javitch JA, Lindsley CW, Winder DG. Conrad KL, et al. Among authors: lindsley cw. Neuropsychopharmacology. 2012 Sep;37(10):2253-66. doi: 10.1038/npp.2012.76. Epub 2012 May 23. Neuropsychopharmacology. 2012. PMID: 22617356 Free PMC article.
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW. Morris LC, et al. Among authors: lindsley cw. J Med Chem. 2014 Dec 11;57(23):10192-7. doi: 10.1021/jm501375c. Epub 2014 Dec 2. J Med Chem. 2014. PMID: 25423411 Free PMC article.
Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core.
Nance KD, Days EL, Weaver CD, Coldren A, Farmer TD, Cho HP, Niswender CM, Blobaum AL, Niswender KD, Lindsley CW. Nance KD, et al. Among authors: lindsley cw. J Med Chem. 2017 Feb 23;60(4):1611-1616. doi: 10.1021/acs.jmedchem.6b01706. Epub 2017 Feb 3. J Med Chem. 2017. PMID: 28103022
761 results