Conn PJ - Search Results

1

Development of allosteric modulators of GPCRs for treatment of CNS disorders.

Nickols HH, Conn PJ. Nickols HH, et al. Among authors: conn pj. Neurobiol Dis. 2014 Jan;61:55-71. doi: 10.1016/j.nbd.2013.09.013. Epub 2013 Sep 27. Neurobiol Dis. 2014. PMID: 24076101 Free PMC article. Review.

2

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ. Chen Y, et al. Among authors: conn pj. Mol Pharmacol. 2007 May;71(5):1389-98. doi: 10.1124/mol.106.032425. Epub 2007 Feb 15. Mol Pharmacol. 2007. PMID: 17303702

3

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.

Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW. Williams R, et al. Among authors: conn pj. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6. doi: 10.1016/j.bmcl.2008.11.104. Epub 2008 Dec 25. Bioorg Med Chem Lett. 2009. PMID: 19097893 Free PMC article.

4

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.

Conn PJ, Christopoulos A, Lindsley CW. Conn PJ, et al. Nat Rev Drug Discov. 2009 Jan;8(1):41-54. doi: 10.1038/nrd2760. Nat Rev Drug Discov. 2009. PMID: 19116626 Free PMC article. Review.

5

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.

Conn PJ, Jones CK, Lindsley CW. Conn PJ, et al. Trends Pharmacol Sci. 2009 Mar;30(3):148-55. doi: 10.1016/j.tips.2008.12.002. Epub 2009 Feb 7. Trends Pharmacol Sci. 2009. PMID: 19201489 Free PMC article. Review.

6

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ. Ayala JE, et al. Among authors: conn pj. Neuropsychopharmacology. 2009 Aug;34(9):2057-71. doi: 10.1038/npp.2009.30. Epub 2009 Mar 18. Neuropsychopharmacology. 2009. PMID: 19295507 Free PMC article.

7

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.

Niswender CM, Johnson KA, Miller NR, Ayala JE, Luo Q, Williams R, Saleh S, Orton D, Weaver CD, Conn PJ. Niswender CM, et al. Among authors: conn pj. Mol Pharmacol. 2010 Mar;77(3):459-68. doi: 10.1124/mol.109.058768. Epub 2009 Dec 21. Mol Pharmacol. 2010. PMID: 20026717 Free PMC article.

8

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM.

Bridges TM, Phillip Kennedy J, Noetzel MJ, Breininger ML, Gentry PR, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: conn pj. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. doi: 10.1016/j.bmcl.2010.01.109. Epub 2010 Feb 1. Bioorg Med Chem Lett. 2010. PMID: 20156687 Free PMC article.

9

The antipsychotic potential of muscarinic allosteric modulation.

Bridges TM, LeBois EP, Hopkins CR, Wood MR, Jones CK, Conn PJ, Lindsley CW. Bridges TM, et al. Among authors: conn pj. Drug News Perspect. 2010 May;23(4):229-40. doi: 10.1358/dnp.2010.23.4.1416977. Drug News Perspect. 2010. PMID: 20520852 Free PMC article. Review.

10

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.

Digby GJ, Shirey JK, Conn PJ. Digby GJ, et al. Among authors: conn pj. Mol Biosyst. 2010 Aug;6(8):1345-54. doi: 10.1039/c002938f. Epub 2010 Jun 25. Mol Biosyst. 2010. PMID: 20582339 Free PMC article. Review.

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