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Structure and function of mRNA export adaptors.
Walsh MJ, Hautbergue GM, Wilson SA. Walsh MJ, et al. Among authors: hautbergue gm. Biochem Soc Trans. 2010 Feb;38(Pt 1):232-6. doi: 10.1042/BST0380232. Biochem Soc Trans. 2010. PMID: 20074066
TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.
Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA. Viphakone N, et al. Among authors: hautbergue gm. Nat Commun. 2012;3:1006. doi: 10.1038/ncomms2005. Nat Commun. 2012. PMID: 22893130 Free PMC article.
Chtop is a component of the dynamic TREX mRNA export complex.
Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA. Chang CT, et al. Among authors: hautbergue gm. EMBO J. 2013 Feb 6;32(3):473-86. doi: 10.1038/emboj.2012.342. Epub 2013 Jan 8. EMBO J. 2013. PMID: 23299939 Free PMC article.
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ. Webster CP, et al. Among authors: hautbergue gm. EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334615 Free PMC article.
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ. Hautbergue GM, et al. Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063. Nat Commun. 2017. PMID: 28677678 Free PMC article.
71 results