Wang L - Search Results

1

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.

Xue X, Wei JL, Xu LL, Xi MY, Xu XL, Liu F, Guo XK, Wang L, Zhang XJ, Zhang MY, Lu MC, Sun HP, You QD. Xue X, et al. Among authors: wang l. J Chem Inf Model. 2013 Oct 28;53(10):2715-29. doi: 10.1021/ci400348f. Epub 2013 Oct 7. J Chem Inf Model. 2013. PMID: 24050442

2

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.

Zhang C, Wang HJ, Bao QC, Wang L, Guo TK, Chen WL, Xu LL, Zhou HS, Bian JL, Yang YR, Sun HP, Xu XL, You QD. Zhang C, et al. Among authors: wang l, wang hj. Oncotarget. 2016 Nov 8;7(45):73593-73606. doi: 10.18632/oncotarget.12435. Oncotarget. 2016. PMID: 27713154 Free PMC article.

3

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Zhang Q, Wu X, Zhou J, Zhang L, Xu X, Zhang L, You Q, Wang L. Zhang Q, et al. Among authors: wang l. Eur J Med Chem. 2021 Jan 15;210:112959. doi: 10.1016/j.ejmech.2020.112959. Epub 2020 Oct 22. Eur J Med Chem. 2021. PMID: 33109397

4

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery.

Wang L, Xu X, Jiang Z, You Q. Wang L, et al. Acta Pharm Sin B. 2020 Oct;10(10):1904-1925. doi: 10.1016/j.apsb.2020.01.018. Epub 2020 Feb 7. Acta Pharm Sin B. 2020. PMID: 33163343 Free PMC article. Review.

5

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Li L, Chen N, Xia D, Xu S, Dai W, Tong Y, Wang L, Jiang Z, You Q, Xu X. Li L, et al. Among authors: wang l. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6. doi: 10.1016/j.chembiol.2021.03.016. Epub 2021 Apr 30. Cell Chem Biol. 2021. PMID: 33932325 Free article.

6

Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds.

Liu H, Qiu W, Sun T, Wang L, Du C, Hu Y, Liu W, Feng F, Chen Y, Sun H. Liu H, et al. Among authors: wang l. Acta Pharm Sin B. 2022 Apr;12(4):1781-1804. doi: 10.1016/j.apsb.2021.12.019. Epub 2021 Dec 31. Acta Pharm Sin B. 2022. PMID: 35847506 Free PMC article. Review.

7

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

Gu J, Wu Q, Zhang Q, You Q, Wang L. Gu J, et al. Among authors: wang l. Eur J Med Chem. 2022 Dec 5;243:114742. doi: 10.1016/j.ejmech.2022.114742. Epub 2022 Sep 9. Eur J Med Chem. 2022. PMID: 36155354 Review.

8

Proximity-enabled bioreactivity to generate covalent peptide inhibitors of p53-Mdm4.

Hoppmann C, Wang L. Hoppmann C, et al. Among authors: wang l. Chem Commun (Camb). 2016 Apr 14;52(29):5140-3. doi: 10.1039/c6cc01226d. Epub 2016 Mar 21. Chem Commun (Camb). 2016. PMID: 26996321

9

Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner.

Zhang B, Shi X, Xu G, Kang W, Zhang W, Zhang S, Cao Y, Qian L, Zhan P, Yan H, To KF, Wang L, Zou X. Zhang B, et al. Among authors: wang l. J Cell Mol Med. 2017 Jul;21(7):1329-1341. doi: 10.1111/jcmm.13063. Epub 2017 Feb 12. J Cell Mol Med. 2017. PMID: 28190297 Free PMC article.

10

Therapeutic peptides: current applications and future directions.

Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, Wang X, Wang R, Fu C. Wang L, et al. Among authors: wang x, wang n, wang r. Signal Transduct Target Ther. 2022 Feb 14;7(1):48. doi: 10.1038/s41392-022-00904-4. Signal Transduct Target Ther. 2022. PMID: 35165272 Free PMC article. Review.

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