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Page 1
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Frye SV, Haffner CD, Maloney PR, Hiner RN, Dorsey GF, Noe RA, Unwalla RJ, Batchelor KW, Bramson HN, Stuart JD, et al. Frye SV, et al. J Med Chem. 1995 Jul 7;38(14):2621-7. doi: 10.1021/jm00014a015. J Med Chem. 1995. PMID: 7629802
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J. Liu F, et al. Among authors: frye sv. J Med Chem. 2009 Dec 24;52(24):7950-3. doi: 10.1021/jm901543m. J Med Chem. 2009. PMID: 19891491 Free PMC article.
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J. Liu F, et al. Among authors: frye sv. J Med Chem. 2010 Aug 12;53(15):5844-57. doi: 10.1021/jm100478y. J Med Chem. 2010. PMID: 20614940 Free PMC article.
Epigenetics: Tools and Technologies.
Janzen WP, Wigle TJ, Jin J, Frye SV. Janzen WP, et al. Among authors: frye sv. Drug Discov Today Technol. 2010 Spring;7(1):e59-e65. doi: 10.1016/j.ddtec.2010.07.004. Drug Discov Today Technol. 2010. PMID: 21243036 Free PMC article.
153 results