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Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T. Ito Y, et al. Among authors: kobayashi s. Arthritis Rheum. 2009 Aug;60(8):2294-303. doi: 10.1002/art.24687. Arthritis Rheum. 2009. PMID: 19644886 Free article.
Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8.
Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, Oku T, Hirayama Y, Yoshitomi H, Hikida M, Yoshifuji H, Mimori T, Watanabe T, Shimizu J. Shiheido H, et al. Among authors: kobayashi s. Immun Inflamm Dis. 2014 Jun;2(1):35-43. doi: 10.1002/iid3.17. Epub 2014 Feb 19. Immun Inflamm Dis. 2014. PMID: 25400923 Free PMC article.
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T. Iguchi-Hashimoto M, et al. Among authors: kobayashi s. PLoS One. 2011;6(10):e27020. doi: 10.1371/journal.pone.0027020. Epub 2011 Oct 27. PLoS One. 2011. PMID: 22046434 Free PMC article.
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