Frankel AE - Search Results

1

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells.

Tanios R, Bekdash A, Kassab E, Stone E, Georgiou G, Frankel AE, Abi-Habib RJ. Tanios R, et al. Among authors: frankel ae. Leuk Res. 2013 Nov;37(11):1565-71. doi: 10.1016/j.leukres.2013.08.007. Epub 2013 Aug 16. Leuk Res. 2013. PMID: 24018014

2

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells.

Khoury O, Ghazale N, Stone E, El-Sibai M, Frankel AE, Abi-Habib RJ. Khoury O, et al. Among authors: frankel ae. J Neurooncol. 2015 Mar;122(1):75-85. doi: 10.1007/s11060-014-1698-5. Epub 2015 Jan 8. J Neurooncol. 2015. PMID: 25567351

3

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity.

Kassab E, Darwish M, Timsah Z, Liu S, Leppla SH, Frankel AE, Abi-Habib RJ. Kassab E, et al. Among authors: frankel ae. Transl Oncol. 2013 Feb;6(1):25-32. doi: 10.1593/tlo.12313. Epub 2013 Feb 1. Transl Oncol. 2013. PMID: 23418614 Free PMC article.

4

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF).

Bekdash A, Darwish M, Timsah Z, Kassab E, Ghanem H, Najjar V, Ghosn M, Nasser S, El-Hajj H, Bazerbachi A, Liu S, Leppla SH, Frankel AE, Abi-Habib RJ. Bekdash A, et al. Among authors: frankel ae. Transl Oncol. 2015 Oct;8(5):347-357. doi: 10.1016/j.tranon.2015.07.001. Transl Oncol. 2015. PMID: 26500025 Free PMC article.

5

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts.

Abi-Habib RJ, Liu S, Bugge TH, Leppla SH, Frankel AE. Abi-Habib RJ, et al. Among authors: frankel ae. Blood. 2004 Oct 1;104(7):2143-8. doi: 10.1182/blood-2004-01-0339. Epub 2004 May 25. Blood. 2004. PMID: 15161668 Free article.

6

Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells.

Agrawal V, Woo JH, Mauldin JP, Jo C, Stone EM, Georgiou G, Frankel AE. Agrawal V, et al. Among authors: frankel ae. Anticancer Drugs. 2012 Jan;23(1):51-64. doi: 10.1097/CAD.0b013e32834ae42b. Anticancer Drugs. 2012. PMID: 21955999

7

In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts.

Agrawal V, Woo JH, Mauldin JP, Stone EM, Meininger CJ, Jo C, Kleypas K, Frenkel EP, Frankel AE. Agrawal V, et al. Among authors: frankel ae. Melanoma Res. 2014 Dec;24(6):556-67. doi: 10.1097/CMR.0000000000000119. Melanoma Res. 2014. PMID: 25304236

8

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types.

Abi-Habib RJ, Singh R, Liu S, Bugge TH, Leppla SH, Frankel AE. Abi-Habib RJ, et al. Among authors: frankel ae. Mol Cancer Ther. 2006 Oct;5(10):2556-62. doi: 10.1158/1535-7163.MCT-06-0315. Mol Cancer Ther. 2006. PMID: 17041100

9

Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.

Burrage LC, Sun Q, Elsea SH, Jiang MM, Nagamani SC, Frankel AE, Stone E, Alters SE, Johnson DE, Rowlinson SW, Georgiou G; Members of Urea Cycle Disorders Consortium; Lee BH. Burrage LC, et al. Among authors: frankel ae. Hum Mol Genet. 2015 Nov 15;24(22):6417-27. doi: 10.1093/hmg/ddv352. Epub 2015 Sep 10. Hum Mol Genet. 2015. PMID: 26358771 Free PMC article.

10

Recombinant human arginase toxicity in mice is reduced by citrulline supplementation.

Mauldin JP, Zeinali I, Kleypas K, Woo JH, Blackwood RS, Jo CH, Stone EM, Georgiou G, Frankel AE. Mauldin JP, et al. Among authors: frankel ae. Transl Oncol. 2012 Feb;5(1):26-31. doi: 10.1593/tlo.11262. Epub 2012 Feb 1. Transl Oncol. 2012. PMID: 22348173 Free PMC article.

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