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Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors.
Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P, Jun D, Kuca K, Korabecny J, Musilek K. Gorecki L, et al. Among authors: schmidt m. ACS Med Chem Lett. 2019 Nov 26;11(1):65-71. doi: 10.1021/acsmedchemlett.9b00477. eCollection 2020 Jan 9. ACS Med Chem Lett. 2019. PMID: 31938465 Free PMC article.
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides.
Kohoutova Z, Malinak D, Andrys R, Svobodova J, Psotka M, Schmidt M, Prchal L, Musilek K. Kohoutova Z, et al. Among authors: schmidt m. J Enzyme Inhib Med Chem. 2022 Dec;37(1):760-767. doi: 10.1080/14756366.2022.2041628. J Enzyme Inhib Med Chem. 2022. PMID: 35193448 Free PMC article.
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