Thompson CH - Search Results

1

Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation.

Campbell CM, Campbell JD, Thompson CH, Galimberti ES, Darbar D, Vanoye CG, George AL Jr. Campbell CM, et al. Among authors: thompson ch. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):960-6. doi: 10.1161/CIRCEP.113.000439. Epub 2013 Sep 4. Circ Arrhythm Electrophysiol. 2013. PMID: 24006450 Free PMC article.

2

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.

Thompson CH, Kahlig KM, George AL Jr. Thompson CH, et al. Epilepsia. 2011 May;52(5):1000-9. doi: 10.1111/j.1528-1167.2011.03040.x. Epub 2011 Mar 31. Epilepsia. 2011. PMID: 21453355 Free PMC article.

3

Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression.

Thompson CH, Porter JC, Kahlig KM, Daniels MA, George AL Jr. Thompson CH, et al. J Biol Chem. 2012 Dec 7;287(50):42001-8. doi: 10.1074/jbc.M112.421883. Epub 2012 Oct 19. J Biol Chem. 2012. PMID: 23086956 Free PMC article.

4

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.

Mistry AM, Thompson CH, Miller AR, Vanoye CG, George AL Jr, Kearney JA. Mistry AM, et al. Among authors: thompson ch. Neurobiol Dis. 2014 May;65:1-11. doi: 10.1016/j.nbd.2014.01.006. Epub 2014 Jan 14. Neurobiol Dis. 2014. PMID: 24434335 Free PMC article.

5

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL Jr. Anderson LL, et al. Among authors: thompson ch. Epilepsia. 2014 Aug;55(8):1274-83. doi: 10.1111/epi.12657. Epub 2014 May 23. Epilepsia. 2014. PMID: 24862204 Free PMC article.

6

CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice.

Thompson CH, Hawkins NA, Kearney JA, George AL Jr. Thompson CH, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1696-1701. doi: 10.1073/pnas.1615774114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137877 Free PMC article.

7

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.

Anderson LL, Hawkins NA, Thompson CH, Kearney JA, George AL Jr. Anderson LL, et al. Among authors: thompson ch. Sci Rep. 2017 May 10;7(1):1682. doi: 10.1038/s41598-017-01851-9. Sci Rep. 2017. PMID: 28490751 Free PMC article.

8

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood.

Simmons CQ, Thompson CH, Cawthon BE, Westlake G, Swoboda KJ, Kiskinis E, Ess KC, George AL Jr. Simmons CQ, et al. Among authors: thompson ch. Neurobiol Dis. 2018 Jul;115:29-38. doi: 10.1016/j.nbd.2018.03.009. Epub 2018 Mar 19. Neurobiol Dis. 2018. PMID: 29567111

9

SCN1A variants associated with sudden infant death syndrome.

Brownstein CA, Goldstein RD, Thompson CH, Haynes RL, Giles E, Sheidley B, Bainbridge M, Haas EA, Mena OJ, Lucas J, Schaber B, Holm IA, George AL, Kinney HC, Poduri AH. Brownstein CA, et al. Among authors: thompson ch. Epilepsia. 2018 Apr;59(4):e56-e62. doi: 10.1111/epi.14055. Epub 2018 Mar 30. Epilepsia. 2018. PMID: 29601086 Free PMC article.

10

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.

Baker EM, Thompson CH, Hawkins NA, Wagnon JL, Wengert ER, Patel MK, George AL Jr, Meisler MH, Kearney JA. Baker EM, et al. Among authors: thompson ch. Epilepsia. 2018 Jun;59(6):1166-1176. doi: 10.1111/epi.14196. Epub 2018 May 21. Epilepsia. 2018. PMID: 29782051 Free PMC article.

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