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DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac.
Biochim Biophys Acta. 2013 Dec;1833(12):3093-3103. doi: 10.1016/j.bbamcr.2013.08.016. Epub 2013 Aug 30.
Biochim Biophys Acta. 2013.
PMID: 23999236
Free article.
Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging.
Bopp A, Wartlick F, Henninger C, Kaina B, Fritz G.
Bopp A, et al. Among authors: wartlick f.
Cell Death Dis. 2013 Mar 21;4(3):e558. doi: 10.1038/cddis.2013.57.
Cell Death Dis. 2013.
PMID: 23519127
Free PMC article.
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Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.
Bopp A, Wartlick F, Henninger C, Schwarz M, Kaina B, Fritz G.
Bopp A, et al. Among authors: wartlick f.
Carcinogenesis. 2015 Mar;36(3):378-89. doi: 10.1093/carcin/bgu323. Epub 2015 Jan 2.
Carcinogenesis. 2015.
PMID: 25556150
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Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
Hinterleitner C, Huelsenbeck J, Henninger C, Wartlick F, Schorr A, Kaina B, Fritz G.
Hinterleitner C, et al. Among authors: wartlick f.
Apoptosis. 2013 Aug;18(8):963-79. doi: 10.1007/s10495-013-0842-6.
Apoptosis. 2013.
PMID: 23624644
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