Stout CD - Search Results

1

Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease.

Tiefenbrunn T, Forli S, Happer M, Gonzalez A, Tsai Y, Soltis M, Elder JH, Olson AJ, Stout CD. Tiefenbrunn T, et al. Among authors: stout cd. Chem Biol Drug Des. 2014 Feb;83(2):141-8. doi: 10.1111/cbdd.12227. Epub 2013 Oct 30. Chem Biol Drug Des. 2014. PMID: 23998903 Free PMC article.

2

Fragment-based screen against HIV protease.

Perryman AL, Zhang Q, Soutter HH, Rosenfeld R, McRee DE, Olson AJ, Elder JE, Stout CD. Perryman AL, et al. Among authors: stout cd. Chem Biol Drug Des. 2010 Mar;75(3):257-68. doi: 10.1111/j.1747-0285.2009.00943.x. Epub 2010 Jan 19. Chem Biol Drug Des. 2010. PMID: 20659109 Free PMC article.

3

Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.

Lin YC, Perryman AL, Olson AJ, Torbett BE, Elder JH, Stout CD. Lin YC, et al. Among authors: stout cd. Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):540-8. doi: 10.1107/S0907444911011681. Epub 2011 May 12. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21636894 Free PMC article.

4

Small molecule regulation of protein conformation by binding in the Flap of HIV protease.

Tiefenbrunn T, Forli S, Baksh MM, Chang MW, Happer M, Lin YC, Perryman AL, Rhee JK, Torbett BE, Olson AJ, Elder JH, Finn MG, Stout CD. Tiefenbrunn T, et al. Among authors: stout cd. ACS Chem Biol. 2013;8(6):1223-31. doi: 10.1021/cb300611p. Epub 2013 Mar 29. ACS Chem Biol. 2013. PMID: 23540839 Free PMC article.

5

Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.

Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD. Heaslet H, et al. Among authors: stout cd. J Mol Biol. 2006 Mar 3;356(4):967-81. doi: 10.1016/j.jmb.2005.11.094. Epub 2005 Dec 20. J Mol Biol. 2006. PMID: 16403521

6

Conformational flexibility in the flap domains of ligand-free HIV protease.

Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee DE, Stout CD. Heaslet H, et al. Among authors: stout cd. Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):866-75. doi: 10.1107/S0907444907029125. Epub 2007 Jul 17. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17642513

7

Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.

Heaslet H, Lin YC, Tam K, Torbett BE, Elder JH, Stout CD. Heaslet H, et al. Among authors: stout cd. Retrovirology. 2007 Jan 9;4:1. doi: 10.1186/1742-4690-4-1. Retrovirology. 2007. PMID: 17212810 Free PMC article.

8

A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.

Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE. Giffin MJ, et al. Among authors: stout cd. J Med Chem. 2008 Oct 23;51(20):6263-70. doi: 10.1021/jm800149m. Epub 2008 Sep 30. J Med Chem. 2008. PMID: 18823110 Free PMC article.

9

AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery.

Tsai Y, McPhillips SE, González A, McPhillips TM, Zinn D, Cohen AE, Feese MD, Bushnell D, Tiefenbrunn T, Stout CD, Ludaescher B, Hedman B, Hodgson KO, Soltis SM. Tsai Y, et al. Among authors: stout cd. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):796-803. doi: 10.1107/S0907444913001984. Epub 2013 Apr 11. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23633588 Free PMC article.

10

High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.

Tiefenbrunn T, Liu W, Chen Y, Katritch V, Stout CD, Fee JA, Cherezov V. Tiefenbrunn T, et al. Among authors: stout cd. PLoS One. 2011;6(7):e22348. doi: 10.1371/journal.pone.0022348. Epub 2011 Jul 21. PLoS One. 2011. PMID: 21814577 Free PMC article.

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