Gonzalez A - Search Results

1

Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease.

Tiefenbrunn T, Forli S, Happer M, Gonzalez A, Tsai Y, Soltis M, Elder JH, Olson AJ, Stout CD. Tiefenbrunn T, et al. Among authors: gonzalez a. Chem Biol Drug Des. 2014 Feb;83(2):141-8. doi: 10.1111/cbdd.12227. Epub 2013 Oct 30. Chem Biol Drug Des. 2014. PMID: 23998903 Free PMC article.

2

AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery.

Tsai Y, McPhillips SE, González A, McPhillips TM, Zinn D, Cohen AE, Feese MD, Bushnell D, Tiefenbrunn T, Stout CD, Ludaescher B, Hedman B, Hodgson KO, Soltis SM. Tsai Y, et al. Among authors: gonzalez a. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):796-803. doi: 10.1107/S0907444913001984. Epub 2013 Apr 11. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23633588 Free PMC article.

3

Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.

Ruben EA, Schwans JP, Sonnett M, Natarajan A, Gonzalez A, Tsai Y, Herschlag D. Ruben EA, et al. Among authors: gonzalez a. Biochemistry. 2013 Feb 12;52(6):1074-81. doi: 10.1021/bi301348x. Epub 2013 Jan 30. Biochemistry. 2013. PMID: 23311398 Free PMC article.

4

Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.

Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11308-13. doi: 10.1073/pnas.1206710110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798413 Free PMC article.

5

Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase.

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. J Am Chem Soc. 2011 Dec 21;133(50):20052-5. doi: 10.1021/ja208050t. Epub 2011 Nov 22. J Am Chem Soc. 2011. PMID: 22053826 Free PMC article.

6

Correction to "Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase".

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. J Am Chem Soc. 2016 Jun 22;138(24):7801-2. doi: 10.1021/jacs.6b04665. Epub 2016 Jun 14. J Am Chem Soc. 2016. PMID: 27299372 No abstract available.

7

Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. Biochemistry. 2013 Nov 5;52(44):7840-55. doi: 10.1021/bi401083b. Epub 2013 Oct 23. Biochemistry. 2013. PMID: 24151972 Free PMC article.

8

Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. Cohen AE, et al. Among authors: gonzalez a. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31. Proc Natl Acad Sci U S A. 2014. PMID: 25362050 Free PMC article.

9

Correction to Uncovering the Determinants of a Highly Perturbed Tyrosine p K_a in the Active Site of Ketosteroid Isomerase.

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. Biochemistry. 2018 Apr 10;57(14):2176. doi: 10.1021/acs.biochem.8b00246. Epub 2018 Mar 27. Biochemistry. 2018. PMID: 29584413 No abstract available.

10

Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.

Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D. Schwans JP, et al. Among authors: gonzalez a. Biochemistry. 2014 Apr 22;53(15):2541-55. doi: 10.1021/bi401671t. Epub 2014 Apr 9. Biochemistry. 2014. PMID: 24597914 Free PMC article.

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