Hu J - Search Results

1

Allosteric activation of functionally asymmetric RAF kinase dimers.

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Cell. 2013 Aug 29;154(5):1036-1046. doi: 10.1016/j.cell.2013.07.046. Cell. 2013. PMID: 23993095 Free PMC article.

2

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Hu J, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72. doi: 10.1073/pnas.1102554108. Epub 2011 Mar 25. Proc Natl Acad Sci U S A. 2011. PMID: 21441104 Free PMC article.

3

Pseudokinases from a structural perspective.

Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. Taylor SS, et al. Among authors: hu j. Biochem Soc Trans. 2013 Aug;41(4):981-6. doi: 10.1042/BST20130120. Biochem Soc Trans. 2013. PMID: 23863167 Free PMC article. Review.

4

Kinases and pseudokinases: lessons from RAF.

Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Shaw AS, et al. Among authors: hu j. Mol Cell Biol. 2014 May;34(9):1538-46. doi: 10.1128/MCB.00057-14. Epub 2014 Feb 24. Mol Cell Biol. 2014. PMID: 24567368 Free PMC article. Review.

5

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH. Wang X, et al. Among authors: hu j. Sci Signal. 2014 Aug 5;7(337):ra74. doi: 10.1126/scisignal.2005147. Sci Signal. 2014. PMID: 25097034 Free PMC article.

6

Kinase regulation by hydrophobic spine assembly in cancer.

Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Hu J, et al. Mol Cell Biol. 2015 Jan;35(1):264-76. doi: 10.1128/MCB.00943-14. Epub 2014 Oct 27. Mol Cell Biol. 2015. PMID: 25348715 Free PMC article.

7

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming.

Banchereau J, Zurawski S, Thompson-Snipes L, Blanck JP, Clayton S, Munk A, Cao Y, Wang Z, Khandelwal S, Hu J, McCoy WH 4th, Palucka KA, Reiter Y, Fremont DH, Zurawski G, Colonna M, Shaw AS, Klechevsky E. Banchereau J, et al. Among authors: hu j. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18885-90. doi: 10.1073/pnas.1205785109. Epub 2012 Oct 29. Proc Natl Acad Sci U S A. 2012. PMID: 23112154 Free PMC article. Clinical Trial.

8

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

Yuan J, Ng WH, Lam PYP, Wang Y, Xia H, Yap J, Guan SP, Lee ASG, Wang M, Baccarini M, Hu J. Yuan J, et al. Among authors: hu j. Oncogene. 2018 Oct;37(43):5719-5734. doi: 10.1038/s41388-018-0365-2. Epub 2018 Jun 21. Oncogene. 2018. PMID: 29930381 Free PMC article.

9

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.

Yuan J, Ng WH, Yap J, Chia B, Huang X, Wang M, Hu J. Yuan J, et al. Among authors: hu j. J Biol Chem. 2018 Sep 14;293(37):14276-14284. doi: 10.1074/jbc.RA118.004597. Epub 2018 Jul 20. J Biol Chem. 2018. PMID: 30030377 Free PMC article.

10

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.

Xu X, Wang X, Todd EM, Jaeger ER, Vella JL, Mooren OL, Feng Y, Hu J, Cooper JA, Morley SC, Huang YH. Xu X, et al. Among authors: hu j. J Immunol. 2016 Sep 1;197(5):1683-91. doi: 10.4049/jimmunol.1600874. Epub 2016 Jul 27. J Immunol. 2016. PMID: 27465533 Free PMC article.

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