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Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay.
Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Wiggers HJ, et al. Among authors: silva js. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2370. doi: 10.1371/journal.pntd.0002370. eCollection 2013. PLoS Negl Trop Dis. 2013. PMID: 23991231 Free PMC article.
'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.
Carvalho I, Andrade P, Campo VL, Guedes PM, Sesti-Costa R, Silva JS, Schenkman S, Dedola S, Hill L, Rejzek M, Nepogodiev SA, Field RA. Carvalho I, et al. Among authors: silva js. Bioorg Med Chem. 2010 Apr 1;18(7):2412-27. doi: 10.1016/j.bmc.2010.02.053. Epub 2010 Mar 2. Bioorg Med Chem. 2010. PMID: 20335038 Free article.
Congenital Chagas disease: time to screen pregnant women?
Sesti-Costa R, Silva JS, Gutierrez FR. Sesti-Costa R, et al. Among authors: silva js. Expert Rev Anti Infect Ther. 2012 Nov;10(11):1279-82. doi: 10.1586/eri.12.122. Expert Rev Anti Infect Ther. 2012. PMID: 23241184
In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles.
Carneiro ZA, Maia PI, Sesti-Costa R, Lopes CD, Pereira TA, Milanezi CM, da Silva MA, Lopez RF, Silva JS, Deflon VM. Carneiro ZA, et al. Among authors: silva js. PLoS Negl Trop Dis. 2014 May 8;8(5):e2847. doi: 10.1371/journal.pntd.0002847. eCollection 2014 May. PLoS Negl Trop Dis. 2014. PMID: 24810753 Free PMC article.
730 results