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Page 1
Targeting QseC signaling and virulence for antibiotic development.
Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, Waldor MK, Williams N, Taussig R, Wei S, Roth M, Hughes DT, Huntley JF, Fina MW, Falck JR, Sperandio V. Rasko DA, et al. Among authors: falck jr. Science. 2008 Aug 22;321(5892):1078-80. doi: 10.1126/science.1160354. Science. 2008. PMID: 18719281 Free PMC article.
QseC inhibitors as an antivirulence approach for Gram-negative pathogens.
Curtis MM, Russell R, Moreira CG, Adebesin AM, Wang C, Williams NS, Taussig R, Stewart D, Zimmern P, Lu B, Prasad RN, Zhu C, Rasko DA, Huntley JF, Falck JR, Sperandio V. Curtis MM, et al. Among authors: falck jr. mBio. 2014 Nov 11;5(6):e02165. doi: 10.1128/mBio.02165-14. mBio. 2014. PMID: 25389178 Free PMC article.
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML. Garcia V, et al. Among authors: falck jr. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25924878 Free PMC article.
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. Senol SP, et al. Among authors: falck jr. Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13. Inflamm Res. 2016. PMID: 26875149
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM. El-Sikhry HE, et al. Among authors: falck jr. PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016. PLoS One. 2016. PMID: 27494529 Free PMC article.
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.
Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML. Garcia V, et al. Among authors: falck jr. Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21. Circ Res. 2017. PMID: 28325781 Free PMC article.
Stereospecific Stille Cross-Couplings Using Mn(II)Cl2.
Dakarapu R, Falck JR. Dakarapu R, et al. Among authors: falck jr. J Org Chem. 2018 Feb 2;83(3):1241-1251. doi: 10.1021/acs.joc.7b02780. Epub 2018 Jan 17. J Org Chem. 2018. PMID: 29320181
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension.
Dakarapu R, Errabelli R, Manthati VL, Michael Adebesin A, Barma DK, Barma D, Garcia V, Zhang F, Laniado Schwartzman M, Falck JR. Dakarapu R, et al. Among authors: falck jr. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126616. doi: 10.1016/j.bmcl.2019.08.020. Epub 2019 Aug 13. Bioorg Med Chem Lett. 2019. PMID: 31439380 Free PMC article.
684 results