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Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML. Garcia V, et al. Among authors: dakarapu r. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 25924878 Free PMC article.
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM. El-Sikhry HE, et al. Among authors: dakarapu r. PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016. PLoS One. 2016. PMID: 27494529 Free PMC article.
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. Senol SP, et al. Among authors: dakarapu r. Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13. Inflamm Res. 2016. PMID: 26875149
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.
Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML. Garcia V, et al. Among authors: dakarapu r. Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21. Circ Res. 2017. PMID: 28325781 Free PMC article.
12 results