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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.
Østergaard ME, Southwell AL, Kordasiewicz H, Watt AT, Skotte NH, Doty CN, Vaid K, Villanueva EB, Swayze EE, Bennett CF, Hayden MR, Seth PP. Østergaard ME, et al. Among authors: seth pp. Nucleic Acids Res. 2013 Nov;41(21):9634-50. doi: 10.1093/nar/gkt725. Epub 2013 Aug 19. Nucleic Acids Res. 2013. PMID: 23963702 Free PMC article.
Synthesis and biological activity of 5-fluorotubercidin.
Wang X, Seth PP, Ranken R, Swayze EE, Migawa MT. Wang X, et al. Among authors: seth pp. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):161-70. doi: 10.1081/ncn-120027825. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043144
Biaryl guanidine inhibitors of in vitro HCV-IRES activity.
Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Osgood SA, Swayze EE, Risen LM. Jefferson EA, et al. Among authors: seth pp. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5139-43. doi: 10.1016/j.bmcl.2004.07.066. Bioorg Med Chem Lett. 2004. PMID: 15380215
Aryl urea analogs with broad-spectrum antibacterial activity.
Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE. Seth PP, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5569-72. doi: 10.1016/j.bmcl.2004.08.059. Bioorg Med Chem Lett. 2004. PMID: 15482926
Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.
Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B. Prakash TP, et al. Among authors: seth pp. J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295. J Med Chem. 2010. PMID: 20108935
124 results