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Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases.
Gensollen T, Bourges C, Rihet P, Rostan A, Millet V, Noguchi T, Bourdon V, Sobol H, Dubuquoy L, Bertin B, Fumery M, Desreumaux P, Colombel JF, Chamaillard M, Hebuterne X, Hofman P, Naquet P, Galland F. Gensollen T, et al. Among authors: hofman p. Inflamm Bowel Dis. 2013 Oct;19(11):2315-25. doi: 10.1097/MIB.0b013e3182a32b03. Inflamm Bowel Dis. 2013. PMID: 23949622 Clinical Trial.
Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration.
Cesaro A, Brest P, Hofman V, Hébuterne X, Wildman S, Ferrua B, Marchetti S, Doglio A, Vouret-Craviari V, Galland F, Naquet P, Mograbi B, Unwin R, Hofman P. Cesaro A, et al. Among authors: hofman p, hofman v. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G32-42. doi: 10.1152/ajpgi.00282.2009. Epub 2010 Feb 25. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20185692 Free article.
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.
Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hébuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P. Brest P, et al. Among authors: hofman p. Nat Genet. 2011 Mar;43(3):242-5. doi: 10.1038/ng.762. Epub 2011 Jan 30. Nat Genet. 2011. PMID: 21278745
1,160 results