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Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Russell AJ, Westwood IM, Crawford MH, Robinson J, Kawamura A, Redfield C, Laurieri N, Lowe ED, Davies SG, Sim E. Russell AJ, et al. Among authors: sim e. Bioorg Med Chem. 2009 Jan 15;17(2):905-18. doi: 10.1016/j.bmc.2008.11.032. Epub 2008 Nov 19. Bioorg Med Chem. 2009. PMID: 19059786
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E. Abuhammad A, et al. Among authors: sim e. PLoS One. 2012;7(12):e52790. doi: 10.1371/journal.pone.0052790. Epub 2012 Dec 28. PLoS One. 2012. PMID: 23285185 Free PMC article.
Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.
Egleton JE, Thinnes CC, Seden PT, Laurieri N, Lee SP, Hadavizadeh KS, Measures AR, Jones AM, Thompson S, Varney A, Wynne GM, Ryan A, Sim E, Russell AJ. Egleton JE, et al. Among authors: sim e. Bioorg Med Chem. 2014 Jun 1;22(11):3030-54. doi: 10.1016/j.bmc.2014.03.015. Epub 2014 Mar 28. Bioorg Med Chem. 2014. PMID: 24758871 Free article.
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1.
Holton SJ, Dairou J, Sandy J, Rodrigues-Lima F, Dupret JM, Noble ME, Sim E. Holton SJ, et al. Among authors: sim e. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt 1):14-6. doi: 10.1107/S1744309104030659. Epub 2004 Dec 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16508079 Free PMC article.
677 results