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Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway.
Höfer R, Dong L, André F, Ginglinger JF, Lugan R, Gavira C, Grec S, Lang G, Memelink J, Van der Krol S, Bouwmeester H, Werck-Reichhart D. Höfer R, et al. Among authors: memelink j. Metab Eng. 2013 Nov;20:221-32. doi: 10.1016/j.ymben.2013.08.001. Epub 2013 Aug 7. Metab Eng. 2013. PMID: 23933465
The seco-iridoid pathway from Catharanthus roseus.
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D. Miettinen K, et al. Among authors: memelink j. Nat Commun. 2014 Apr 7;5:3606. doi: 10.1038/ncomms4606. Nat Commun. 2014. PMID: 24710322 Free PMC article.
Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma.
Simkin AJ, Miettinen K, Claudel P, Burlat V, Guirimand G, Courdavault V, Papon N, Meyer S, Godet S, St-Pierre B, Giglioli-Guivarc'h N, Fischer MJ, Memelink J, Clastre M. Simkin AJ, et al. Among authors: memelink j. Phytochemistry. 2013 Jan;85:36-43. doi: 10.1016/j.phytochem.2012.09.014. Epub 2012 Oct 24. Phytochemistry. 2013. PMID: 23102596
CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data.
Van Moerkercke A, Fabris M, Pollier J, Baart GJ, Rombauts S, Hasnain G, Rischer H, Memelink J, Oksman-Caldentey KM, Goossens A. Van Moerkercke A, et al. Among authors: memelink j. Plant Cell Physiol. 2013 May;54(5):673-85. doi: 10.1093/pcp/pct039. Epub 2013 Mar 14. Plant Cell Physiol. 2013. PMID: 23493402
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.
Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A. Van Moerkercke A, et al. Among authors: memelink j. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15. Proc Natl Acad Sci U S A. 2015. PMID: 26080427 Free PMC article.
The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus.
Van Moerkercke A, Steensma P, Gariboldi I, Espoz J, Purnama PC, Schweizer F, Miettinen K, Vanden Bossche R, De Clercq R, Memelink J, Goossens A. Van Moerkercke A, et al. Among authors: memelink j. Plant J. 2016 Oct;88(1):3-12. doi: 10.1111/tpj.13230. Epub 2016 Aug 13. Plant J. 2016. PMID: 27342401 Free article.
80 results