Elens L - Search Results

1

A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.

de Graan AJ, Elens L, Smid M, Martens JW, Sparreboom A, Nieuweboer AJ, Friberg LE, Elbouazzaoui S, Wiemer EA, van der Holt B, Verweij J, van Schaik RH, Mathijssen RH. de Graan AJ, et al. Among authors: elens l. Clin Cancer Res. 2013 Sep 15;19(18):5210-7. doi: 10.1158/1078-0432.CCR-13-0487. Epub 2013 Aug 5. Clin Cancer Res. 2013. PMID: 23918604

2

Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.

de Graan AJ, Lancaster CS, Obaidat A, Hagenbuch B, Elens L, Friberg LE, de Bruijn P, Hu S, Gibson AA, Bruun GH, Corydon TJ, Mikkelsen TS, Walker AL, Du G, Loos WJ, van Schaik RH, Baker SD, Mathijssen RH, Sparreboom A. de Graan AJ, et al. Among authors: elens l. Clin Cancer Res. 2012 Aug 15;18(16):4433-40. doi: 10.1158/1078-0432.CCR-12-0761. Epub 2012 Jun 18. Clin Cancer Res. 2012. PMID: 22711709 Free PMC article.

3

CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.

de Graan AJ, Elens L, Sprowl JA, Sparreboom A, Friberg LE, van der Holt B, de Raaf PJ, de Bruijn P, Engels FK, Eskens FA, Wiemer EA, Verweij J, Mathijssen RH, van Schaik RH. de Graan AJ, et al. Among authors: elens l. Clin Cancer Res. 2013 Jun 15;19(12):3316-24. doi: 10.1158/1078-0432.CCR-12-3786. Epub 2013 May 2. Clin Cancer Res. 2013. PMID: 23640974 Free PMC article.

4

A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

Elens L, Bouamar R, Hesselink DA, Haufroid V, van der Heiden IP, van Gelder T, van Schaik RH. Elens L, et al. Clin Chem. 2011 Nov;57(11):1574-83. doi: 10.1373/clinchem.2011.165613. Epub 2011 Sep 8. Clin Chem. 2011. PMID: 21903774 Free article. Clinical Trial.

5

CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.

Elens L, van Gelder T, Hesselink DA, Haufroid V, van Schaik RH. Elens L, et al. Pharmacogenomics. 2013 Jan;14(1):47-62. doi: 10.2217/pgs.12.187. Pharmacogenomics. 2013. PMID: 23252948 Review.

6

Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.

Elens L, Nieuweboer AJ, Clarke SJ, Charles KA, de Graan AJ, Haufroid V, van Gelder T, Mathijssen RH, van Schaik RH. Elens L, et al. Pharmacogenet Genomics. 2013 Mar;23(3):148-55. doi: 10.1097/FPC.0b013e32835dc113. Pharmacogenet Genomics. 2013. PMID: 23324807

7

CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.

Elens L, Nieuweboer A, Clarke SJ, Charles KA, de Graan AJ, Haufroid V, Mathijssen RH, van Schaik RH. Elens L, et al. Pharmacogenomics. 2013 Jan;14(2):137-49. doi: 10.2217/pgs.12.202. Pharmacogenomics. 2013. PMID: 23327575

8

The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation.

Hesselink DA, Bouamar R, Elens L, van Schaik RH, van Gelder T. Hesselink DA, et al. Among authors: elens l. Clin Pharmacokinet. 2014 Feb;53(2):123-39. doi: 10.1007/s40262-013-0120-3. Clin Pharmacokinet. 2014. PMID: 24249597 Review.

9

Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

Elens L, Becker ML, Haufroid V, Hofman A, Visser LE, Uitterlinden AG, Stricker BCh, van Schaik RH. Elens L, et al. Pharmacogenet Genomics. 2011 Dec;21(12):861-6. doi: 10.1097/FPC.0b013e32834c6edb. Pharmacogenet Genomics. 2011. PMID: 21946898

10

The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.

Elens L, Bouamar R, Hesselink DA, Haufroid V, van Gelder T, van Schaik RH. Elens L, et al. Pharmacogenet Genomics. 2012 May;22(5):373-80. doi: 10.1097/FPC.0b013e328351f3c1. Pharmacogenet Genomics. 2012. PMID: 22388796

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