Fesik SW - Search Results

1

Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.

Patrone JD, Kennedy JP, Frank AO, Feldkamp MD, Vangamudi B, Pelz NF, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW. Patrone JD, et al. Among authors: fesik sw. ACS Med Chem Lett. 2013 Jul 11;4(7):601-605. doi: 10.1021/ml400032y. ACS Med Chem Lett. 2013. PMID: 23914285 Free PMC article.

2

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A.

Souza-Fagundes EM, Frank AO, Feldkamp MD, Dorset DC, Chazin WJ, Rossanese OW, Olejniczak ET, Fesik SW. Souza-Fagundes EM, et al. Among authors: fesik sw. Anal Biochem. 2012 Feb 15;421(2):742-9. doi: 10.1016/j.ab.2011.11.025. Epub 2011 Dec 1. Anal Biochem. 2012. PMID: 22197419 Free PMC article.

3

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Sun Q, et al. Among authors: fesik sw. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. doi: 10.1002/anie.201201358. Epub 2012 May 8. Angew Chem Int Ed Engl. 2012. PMID: 22566140 Free PMC article. No abstract available.

4

Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.

Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW. Friberg A, et al. Among authors: fesik sw. J Med Chem. 2013 Jan 10;56(1):15-30. doi: 10.1021/jm301448p. Epub 2012 Dec 17. J Med Chem. 2013. PMID: 23244564 Free PMC article.

5

Fragment-based drug discovery using NMR spectroscopy.

Harner MJ, Frank AO, Fesik SW. Harner MJ, et al. Among authors: fesik sw. J Biomol NMR. 2013 Jun;56(2):65-75. doi: 10.1007/s10858-013-9740-z. Epub 2013 May 18. J Biomol NMR. 2013. PMID: 23686385 Free PMC article. Review.

6

Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein.

Feldkamp MD, Frank AO, Kennedy JP, Patrone JD, Vangamudi B, Waterson AG, Fesik SW, Chazin WJ. Feldkamp MD, et al. Among authors: fesik sw. Biochemistry. 2013 Sep 17;52(37):6515-24. doi: 10.1021/bi400542z. Epub 2013 Sep 6. Biochemistry. 2013. PMID: 23962067 Free PMC article.

7

Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.

Frank AO, Feldkamp MD, Kennedy JP, Waterson AG, Pelz NF, Patrone JD, Vangamudi B, Camper DV, Rossanese OW, Chazin WJ, Fesik SW. Frank AO, et al. Among authors: fesik sw. J Med Chem. 2013 Nov 27;56(22):9242-50. doi: 10.1021/jm401333u. Epub 2013 Nov 11. J Med Chem. 2013. PMID: 24147804 Free PMC article.

8

Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A.

Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D, Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW. Frank AO, et al. Among authors: fesik sw. J Med Chem. 2014 Mar 27;57(6):2455-61. doi: 10.1021/jm401730y. Epub 2014 Feb 19. J Med Chem. 2014. PMID: 24491171 Free PMC article.

9

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Burns MC, Sun Q, Daniels RN, Camper D, Kennedy JP, Phan J, Olejniczak ET, Lee T, Waterson AG, Rossanese OW, Fesik SW. Burns MC, et al. Among authors: fesik sw. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. doi: 10.1073/pnas.1315798111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550516 Free PMC article.

10

Fragment-based screening of the bromodomain of ATAD2.

Harner MJ, Chauder BA, Phan J, Fesik SW. Harner MJ, et al. Among authors: fesik sw. J Med Chem. 2014 Nov 26;57(22):9687-92. doi: 10.1021/jm501035j. Epub 2014 Nov 11. J Med Chem. 2014. PMID: 25314628 Free PMC article.

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