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Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.
Lai ZW, Borsuk R, Shadakshari A, Yu J, Dawood M, Garcia R, Francis L, Tily H, Bartos A, Faraone SV, Phillips P, Perl A. Lai ZW, et al. Among authors: phillips p. J Immunol. 2013 Sep 1;191(5):2236-46. doi: 10.4049/jimmunol.1301005. Epub 2013 Aug 2. J Immunol. 2013. PMID: 23913957 Free PMC article.
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.
Lai ZW, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, Miklossy G, Jimah J, Doherty E, Tily H, Francis L, Garcia R, Dawood M, Yu J, Ramos I, Coman I, Faraone SV, Phillips PE, Perl A. Lai ZW, et al. Arthritis Rheum. 2012 Sep;64(9):2937-46. doi: 10.1002/art.34502. Arthritis Rheum. 2012. PMID: 22549432 Free PMC article. Clinical Trial.
Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial.
Lai ZW, Kelly R, Winans T, Marchena I, Shadakshari A, Yu J, Dawood M, Garcia R, Tily H, Francis L, Faraone SV, Phillips PE, Perl A. Lai ZW, et al. Lancet. 2018 Mar 24;391(10126):1186-1196. doi: 10.1016/S0140-6736(18)30485-9. Epub 2018 Mar 15. Lancet. 2018. PMID: 29551338 Free PMC article. Clinical Trial.
2,732 results