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Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.
Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G. Zhao X, et al. Among authors: chen a, chen w. Blood. 2014 Mar 13;123(11):1729-38. doi: 10.1182/blood-2013-03-489575. Epub 2014 Jan 21. Blood. 2014. PMID: 24449215 Free PMC article.
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. Leddin M, et al. Among authors: chen w. Blood. 2011 Mar 10;117(10):2827-38. doi: 10.1182/blood-2010-08-302976. Epub 2011 Jan 14. Blood. 2011. PMID: 21239694 Free PMC article.
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA. Roudaia L, et al. Among authors: chen w. Blood. 2009 Mar 26;113(13):3070-9. doi: 10.1182/blood-2008-03-147207. Epub 2009 Jan 29. Blood. 2009. PMID: 19179469 Free PMC article.
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