Timmers LF - Search Results

1

Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.

Pauli I, dos Santos RN, Rostirolla DC, Martinelli LK, Ducati RG, Timmers LF, Basso LA, Santos DS, Guido RV, Andricopulo AD, Norberto de Souza O. Pauli I, et al. Among authors: timmers lf. J Chem Inf Model. 2013 Sep 23;53(9):2390-401. doi: 10.1021/ci400202t. Epub 2013 Aug 20. J Chem Inf Model. 2013. PMID: 23889525

2

Structural bioinformatics study of PNP from Listeria monocytogenes.

Timmers LF, Caceres RA, Basso LA, Santos DS, De Azevedo WF Jr. Timmers LF, et al. Protein Pept Lett. 2008;15(8):843-9. doi: 10.2174/092986608785203728. Protein Pept Lett. 2008. PMID: 18855758

3

Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.

Sánchez-Quitian ZA, Timmers LF, Caceres RA, Rehm JG, Thompson CE, Basso LA, de Azevedo WF Jr, Santos DS. Sánchez-Quitian ZA, et al. Among authors: timmers lf. Arch Biochem Biophys. 2011 May 1;509(1):108-15. doi: 10.1016/j.abb.2011.01.022. Epub 2011 Feb 2. Arch Biochem Biophys. 2011. PMID: 21295009

4

Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir.

Caceres RA, Timmers LF, Ducati RG, da Silva DO, Basso LA, de Azevedo WF Jr, Santos DS. Caceres RA, et al. Among authors: timmers lf. Biochimie. 2012 Jan;94(1):155-65. doi: 10.1016/j.biochi.2011.10.003. Epub 2011 Oct 20. Biochimie. 2012. PMID: 22033138 Free article.

5

Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.

Jaskulski L, Rosado LA, Rostirolla DC, Timmers LF, de Souza ON, Santos DS, Basso LA. Jaskulski L, et al. Among authors: timmers lf. Arch Biochem Biophys. 2013 Aug 1;536(1):53-63. doi: 10.1016/j.abb.2013.05.012. Epub 2013 Jun 10. Arch Biochem Biophys. 2013. PMID: 23756762 Free article.

6

Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity.

Renck D, Machado P, Souto AA, Rosado LA, Erig T, Campos MM, Farias CB, Roesler R, Timmers LF, de Souza ON, Santos DS, Basso LA. Renck D, et al. Among authors: timmers lf. J Med Chem. 2013 Nov 14;56(21):8892-902. doi: 10.1021/jm401389u. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24131420

7

Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only.

Rotta M, Timmers LFSM, Sequeiros-Borja C, Bizarro CV, de Souza ON, Santos DS, Basso LA. Rotta M, et al. Sci Rep. 2017 Jul 28;7(1):6826. doi: 10.1038/s41598-017-07266-w. Sci Rep. 2017. PMID: 28754992 Free PMC article.

8

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.

Muradás TC, Abbadi BL, Villela AD, Macchi FS, Bergo PF, de Freitas TF, Sperotto NDM, Timmers LFSM, Norberto de Souza O, Picada JN, Fachini J, da Silva JB, de Albuquerque NCP, Habenschus MD, Carrão DB, Rocha BA, Barbosa Junior F, de Oliveira ARM, Mascarello A, Neuenfeldf P, Nunes RJ, Morbidoni HR, Campos MM, Basso LA, Rodrigues-Junior VS. Muradás TC, et al. PLoS One. 2018 Aug 16;13(8):e0202568. doi: 10.1371/journal.pone.0202568. eCollection 2018. PLoS One. 2018. PMID: 30114296 Free PMC article.

9

Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs.

Nunes JES, Duque MA, de Freitas TF, Galina L, Timmers LFSM, Bizarro CV, Machado P, Basso LA, Ducati RG. Nunes JES, et al. Molecules. 2020 Mar 11;25(6):1259. doi: 10.3390/molecules25061259. Molecules. 2020. PMID: 32168746 Free PMC article. Review.

10

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice.

Lobo MM, Oliveira SM, Brusco I, Machado P, Timmers LF, de Souza ON, Martins MA, Bonacorso HG, Dos Santos JM, Canova B, da Silva TV, Zanatta N. Lobo MM, et al. Among authors: timmers lf. Eur J Med Chem. 2015 Sep 18;102:143-52. doi: 10.1016/j.ejmech.2015.07.036. Epub 2015 Jul 23. Eur J Med Chem. 2015. PMID: 26263246

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