Abel U - Search Results

1

Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.

Kubas H, Meyer U, Krueger B, Hechenberger M, Vanejevs M, Zemribo R, Kauss V, Ambartsumova R, Pyatkin I, Polosukhin AI, Abel U. Kubas H, et al. Among authors: abel u. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4493-500. doi: 10.1016/j.bmcl.2013.06.049. Epub 2013 Jun 25. Bioorg Med Chem Lett. 2013. PMID: 23856046

2

Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators.

Kubas H, Meyer U, Hechenberger M, Klein KU, Plitt P, Zemribo R, Spexgoor HW, van Assema SG, Abel U. Kubas H, et al. Among authors: abel u. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6370-6. doi: 10.1016/j.bmcl.2013.09.059. Epub 2013 Sep 29. Bioorg Med Chem Lett. 2013. PMID: 24125886

3

Synthesis of 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides and their evaluation as ligands for NMDA receptor glycine binding site.

Bluke Z, Paass E, Sladek M, Abel U, Kauss V. Bluke Z, et al. Among authors: abel u. J Enzyme Inhib Med Chem. 2016 Aug;31(4):664-73. doi: 10.3109/14756366.2015.1057722. Epub 2015 Jun 26. J Enzyme Inhib Med Chem. 2016. PMID: 26114309 Free article.

4

Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile.

Abel U, Simon W, Eckard P, Hansske FG. Abel U, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3292-7. doi: 10.1016/j.bmcl.2006.03.029. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621542

5

Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.

Abel U, Schlüter T, Schulz A, Hambruch E, Steeneck C, Hornberger M, Hoffmann T, Perović-Ottstadt S, Kinzel O, Burnet M, Deuschle U, Kremoser C. Abel U, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4911-7. doi: 10.1016/j.bmcl.2010.06.084. Epub 2010 Jun 19. Bioorg Med Chem Lett. 2010. PMID: 20638278

6

Modern methods to produce natural-product libraries.

Abel U, Koch C, Speitling M, Hansske FG. Abel U, et al. Curr Opin Chem Biol. 2002 Aug;6(4):453-8. doi: 10.1016/s1367-5931(02)00338-1. Curr Opin Chem Biol. 2002. PMID: 12133720 Review.

7

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.

Deuschle U, Schüler J, Schulz A, Schlüter T, Kinzel O, Abel U, Kremoser C. Deuschle U, et al. Among authors: abel u. PLoS One. 2012;7(10):e43044. doi: 10.1371/journal.pone.0043044. Epub 2012 Oct 9. PLoS One. 2012. PMID: 23056173 Free PMC article.

8

"@-Tides": the 1,2-dihydro-3(6H)-pyridinone unit as a beta-strand mimic.

Phillips ST, Rezac M, Abel U, Kossenjans M, Bartlett PA. Phillips ST, et al. Among authors: abel u. J Am Chem Soc. 2002 Jan 9;124(1):58-66. doi: 10.1021/ja0168460. J Am Chem Soc. 2002. PMID: 11772062

9

Investigation of the GnRH antagonist degarelix isomerization in biological matrices.

Ferrazzano L, Tolomelli A, Guryanov I, Macis M, Abel U, Ricci A, Cabri W. Ferrazzano L, et al. Among authors: abel u. Pharmacol Res Perspect. 2023 Aug;11(4):e01117. doi: 10.1002/prp2.1117. Pharmacol Res Perspect. 2023. PMID: 37455491 Free PMC article.

10

Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions-A calibration approach.

Kopp-Schneider A, Wiesenfarth M, Witt R, Edelmann D, Witt O, Abel U. Kopp-Schneider A, et al. Among authors: abel u. Biom J. 2019 May;61(3):488-502. doi: 10.1002/bimj.201700209. Epub 2018 Sep 2. Biom J. 2019. PMID: 30175405

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