McKerrow JH - Search Results

1

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].

Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Nishino M, et al. Among authors: mckerrow jh. Elife. 2013 Jul 9;2:e00712. doi: 10.7554/eLife.00712. Elife. 2013. PMID: 23853713 Free PMC article.

2

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.

Mackey ZB, Koupparis K, Nishino M, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. Chem Biol Drug Des. 2011 Sep;78(3):454-63. doi: 10.1111/j.1747-0285.2011.01156.x. Epub 2011 Jul 14. Chem Biol Drug Des. 2011. PMID: 21668652 Free PMC article.

3

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. Mashiyama ST, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2012;6(12):e1942. doi: 10.1371/journal.pntd.0001942. Epub 2012 Dec 6. PLoS Negl Trop Dis. 2012. PMID: 23236535 Free PMC article.

4

Drug discovery and development for neglected parasitic diseases.

Renslo AR, McKerrow JH. Renslo AR, et al. Among authors: mckerrow jh. Nat Chem Biol. 2006 Dec;2(12):701-10. doi: 10.1038/nchembio837. Nat Chem Biol. 2006. PMID: 17108988 Review.

5

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.

6

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.

Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. Jaishankar P, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2008 Jan 15;18(2):624-8. doi: 10.1016/j.bmcl.2007.11.070. Epub 2007 Nov 22. Bioorg Med Chem Lett. 2008. PMID: 18055204

7

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.

Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Bryant C, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19773167 Free PMC article.

8

Divergent modes of enzyme inhibition in a homologous structure-activity series.

Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Ferreira RS, et al. Among authors: mckerrow jh. J Med Chem. 2009 Aug 27;52(16):5005-8. doi: 10.1021/jm9009229. J Med Chem. 2009. PMID: 19637873 Free PMC article.

9

Protease inhibitors targeting coronavirus and filovirus entry.

Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R Jr, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Zhou Y, et al. Among authors: mckerrow jh. Antiviral Res. 2015 Apr;116:76-84. doi: 10.1016/j.antiviral.2015.01.011. Epub 2015 Feb 7. Antiviral Res. 2015. PMID: 25666761 Free PMC article.

10

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.

Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Debnath A, et al. Among authors: mckerrow jh. Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820073 Free PMC article.

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