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E2F8 is essential for polyploidization in mammalian cells.
Pandit SK, Westendorp B, Nantasanti S, van Liere E, Tooten PC, Cornelissen PW, Toussaint MJ, Lamers WH, de Bruin A. Pandit SK, et al. Among authors: de bruin a. Nat Cell Biol. 2012 Nov;14(11):1181-91. doi: 10.1038/ncb2585. Epub 2012 Oct 14. Nat Cell Biol. 2012. PMID: 23064264
HIF proteins connect the RB-E2F factors to angiogenesis.
Bakker WJ, Weijts BG, Westendorp B, de Bruin A. Bakker WJ, et al. Among authors: de bruin a. Transcription. 2013 Mar-Apr;4(2):62-6. doi: 10.4161/trns.23680. Epub 2013 Feb 14. Transcription. 2013. PMID: 23412359 Free PMC article.
Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.
Matondo RB, Toussaint MJ, Govaert KM, van Vuuren LD, Nantasanti S, Nijkamp MW, Pandit SK, Tooten PC, Koster MH, Holleman K, Schot A, Gu G, Spee B, Roskams T, Rinkes IB, Schotanus B, Kranenburg O, de Bruin A. Matondo RB, et al. Among authors: de bruin a. Oncotarget. 2016 Aug 23;7(34):54662-54675. doi: 10.18632/oncotarget.9952. Oncotarget. 2016. PMID: 27323406 Free PMC article.
E2f8 mediates tumor suppression in postnatal liver development.
Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G. Kent LN, et al. Among authors: de bruin a. J Clin Invest. 2016 Aug 1;126(8):2955-69. doi: 10.1172/JCI85506. Epub 2016 Jul 25. J Clin Invest. 2016. PMID: 27454291 Free PMC article.
392 results