Figg NL - Search Results

1

Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Yu E, et al. Among authors: figg nl. Circulation. 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10. Circulation. 2013. PMID: 23841983

2

Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice.

Mercer J, Figg N, Stoneman V, Braganza D, Bennett MR. Mercer J, et al. Circ Res. 2005 Apr 1;96(6):667-74. doi: 10.1161/01.RES.0000161069.15577.ca. Epub 2005 Mar 3. Circ Res. 2005. PMID: 15746445

3

Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism.

Rosner D, Stoneman V, Littlewood T, McCarthy N, Figg N, Wang Y, Tellides G, Bennett M. Rosner D, et al. Am J Pathol. 2006 Jun;168(6):2054-63. doi: 10.2353/ajpath.2006.050473. Am J Pathol. 2006. PMID: 16723718 Free PMC article.

4

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.

Clarke MC, Figg N, Maguire JJ, Davenport AP, Goddard M, Littlewood TD, Bennett MR. Clarke MC, et al. Nat Med. 2006 Sep;12(9):1075-80. doi: 10.1038/nm1459. Epub 2006 Aug 6. Nat Med. 2006. PMID: 16892061

5

Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques.

Stoneman V, Braganza D, Figg N, Mercer J, Lang R, Goddard M, Bennett M. Stoneman V, et al. Circ Res. 2007 Mar 30;100(6):884-93. doi: 10.1161/01.RES.0000260802.75766.00. Epub 2007 Feb 22. Circ Res. 2007. PMID: 17322176 Free PMC article.

6

Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment.

Kavurma MM, Figg N, Bennett MR, Mercer J, Khachigian LM, Littlewood TD. Kavurma MM, et al. Biochem J. 2007 Oct 1;407(1):79-87. doi: 10.1042/BJ20070380. Biochem J. 2007. PMID: 17600529 Free PMC article.

7

Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.

Allard D, Figg N, Bennett MR, Littlewood TD. Allard D, et al. J Biol Chem. 2008 Jul 11;283(28):19739-47. doi: 10.1074/jbc.M710098200. Epub 2008 May 5. J Biol Chem. 2008. PMID: 18458087 Free article.

8

Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration.

Clarke MC, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M, Bennett MR. Clarke MC, et al. Circ Res. 2008 Jun 20;102(12):1529-38. doi: 10.1161/CIRCRESAHA.108.175976. Epub 2008 May 22. Circ Res. 2008. PMID: 18497329

9

Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis.

Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM. Shroff RC, et al. Circulation. 2008 Oct 21;118(17):1748-57. doi: 10.1161/CIRCULATIONAHA.108.783738. Epub 2008 Oct 6. Circulation. 2008. PMID: 18838561

10

Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis.

Clarke MC, Talib S, Figg NL, Bennett MR. Clarke MC, et al. Among authors: figg nl. Circ Res. 2010 Feb 5;106(2):363-72. doi: 10.1161/CIRCRESAHA.109.208389. Epub 2009 Nov 19. Circ Res. 2010. PMID: 19926874

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