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Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.
Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R. Yerges-Armstrong LM, et al. Among authors: horenstein rb. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11. Clin Pharmacol Ther. 2013. PMID: 23839601 Free PMC article. Clinical Trial.
Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R. Ellero-Simatos S, et al. Among authors: horenstein rb. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3(7):e125. doi: 10.1038/psp.2014.22. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25029353 Free PMC article.
Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.
Ellero-Simatos S, Beitelshees AL, Lewis JP, Yerges-Armstrong LM, Georgiades A, Dane A, Harms AC, Strassburg K, Guled F, Hendriks MM, Horenstein RB, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R; Pharmacometabolomics Research Network. Ellero-Simatos S, et al. Among authors: horenstein rb. J Am Heart Assoc. 2015 Oct 26;4(10):e002203. doi: 10.1161/JAHA.115.002203. J Am Heart Assoc. 2015. PMID: 26504148 Free PMC article. Clinical Trial.
Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Lewis JP, Fisch AS, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Shen H, Tanner K, Horenstein RB, Pakzy R, Tantry US, Bliden KP, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: horenstein rb. Clin Pharmacol Ther. 2011 Oct;90(4):568-74. doi: 10.1038/clpt.2011.194. Epub 2011 Aug 31. Clin Pharmacol Ther. 2011. PMID: 21881565 Free PMC article. Clinical Trial.
The CYP2C19*17 variant is not independently associated with clopidogrel response.
Lewis JP, Stephens SH, Horenstein RB, O'Connell JR, Ryan K, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Mitchell BD, Shuldiner AR. Lewis JP, et al. Among authors: horenstein rb. J Thromb Haemost. 2013 Sep;11(9):1640-6. doi: 10.1111/jth.12342. J Thromb Haemost. 2013. PMID: 23809542 Free PMC article.
Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.
Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP. Backman JD, et al. Among authors: horenstein rb. Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11. Clin Transl Sci. 2017. PMID: 28075528 Free PMC article.
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