Wroblewski VJ - Search Results

1

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys.

Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Myers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A. Adams AC, et al. Among authors: wroblewski vj. PLoS One. 2013 Jun 18;8(6):e65763. doi: 10.1371/journal.pone.0065763. Print 2013. PLoS One. 2013. PMID: 23823755 Free PMC article.

2

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ. Kharitonenkov A, et al. Among authors: wroblewski vj. Endocrinology. 2007 Feb;148(2):774-81. doi: 10.1210/en.2006-1168. Epub 2006 Oct 26. Endocrinology. 2007. PMID: 17068132

3

FGF-21 as a novel metabolic regulator.

Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB. Kharitonenkov A, et al. Among authors: wroblewski vj. J Clin Invest. 2005 Jun;115(6):1627-35. doi: 10.1172/JCI23606. Epub 2005 May 2. J Clin Invest. 2005. PMID: 15902306 Free PMC article.

4

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.

Kharitonenkov A, Beals JM, Micanovic R, Strifler BA, Rathnachalam R, Wroblewski VJ, Li S, Koester A, Ford AM, Coskun T, Dunbar JD, Cheng CC, Frye CC, Bumol TF, Moller DE. Kharitonenkov A, et al. Among authors: wroblewski vj. PLoS One. 2013;8(3):e58575. doi: 10.1371/journal.pone.0058575. Epub 2013 Mar 11. PLoS One. 2013. PMID: 23536797 Free PMC article.

5

Disposition of Basal Insulin Peglispro Compared with 20-kDa Polyethylene Glycol in Rats Following a Single Intravenous or Subcutaneous Dose.

Knadler MP, Ellis BB, Brown-Augsburger PL, Murphy AT, Martin JA, Wroblewski VJ. Knadler MP, et al. Among authors: wroblewski vj. Drug Metab Dispos. 2015 Oct;43(10):1477-83. doi: 10.1124/dmd.115.064337. Epub 2015 Jul 14. Drug Metab Dispos. 2015. PMID: 26175543

6

Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting.

Smith RC, Cramer MS, Mitchell PJ, Capen A, Huber L, Wang R, Myers L, Jones BE, Eastwood BJ, Ballard D, Hanson J, Credille KM, Wroblewski VJ, Lin BK, Heuer JG. Smith RC, et al. Among authors: wroblewski vj. Mol Cancer Ther. 2015 Jul;14(7):1661-70. doi: 10.1158/1535-7163.MCT-14-0681. Epub 2015 Apr 23. Mol Cancer Ther. 2015. PMID: 25908685

7

Quantitative characterization of the mechanism of action and impact of a 'proteolysis-permitting' anti-PCSK9 antibody.

Hansen RJ, Berna MJ, Sperry AE, Beyer TP, Wroblewski VJ, Schroeder KM, Eacho PI. Hansen RJ, et al. Among authors: wroblewski vj. MAbs. 2017 Feb/Mar;9(2):285-296. doi: 10.1080/19420862.2016.1270490. MAbs. 2017. PMID: 27981884 Free PMC article.

8

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Wroblewski VJ, McCloud C, Davis K, Manetta J, Micanovic R, Witcher DR. Wroblewski VJ, et al. Drug Metab Dispos. 2003 Apr;31(4):502-7. doi: 10.1124/dmd.31.4.502. Drug Metab Dispos. 2003. PMID: 12642478

9

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody.

Schroeder KM, Beyer TP, Hansen RJ, Han B, Pickard RT, Wroblewski VJ, Kowala MC, Eacho PI. Schroeder KM, et al. Among authors: wroblewski vj. J Lipid Res. 2015 Nov;56(11):2124-32. doi: 10.1194/jlr.M061903. Epub 2015 Sep 20. J Lipid Res. 2015. PMID: 26392590 Free PMC article.

10

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.

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