Rubinsztein DC - Search Results

1

IGF-1 receptor antagonism inhibits autophagy.

Renna M, Bento CF, Fleming A, Menzies FM, Siddiqi FH, Ravikumar B, Puri C, Garcia-Arencibia M, Sadiq O, Corrochano S, Carter S, Brown SD, Acevedo-Arozena A, Rubinsztein DC. Renna M, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2013 Nov 15;22(22):4528-44. doi: 10.1093/hmg/ddt300. Epub 2013 Jun 25. Hum Mol Genet. 2013. PMID: 23804751 Free PMC article.

2

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.

Wyttenbach A, Swartz J, Kita H, Thykjaer T, Carmichael J, Bradley J, Brown R, Maxwell M, Schapira A, Orntoft TF, Kato K, Rubinsztein DC. Wyttenbach A, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2001 Aug 15;10(17):1829-45. doi: 10.1093/hmg/10.17.1829. Hum Mol Genet. 2001. PMID: 11532992

3

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2002 May 1;11(9):1107-17. doi: 10.1093/hmg/11.9.1107. Hum Mol Genet. 2002. PMID: 11978769

4

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.

Wyttenbach A, Sauvageot O, Carmichael J, Diaz-Latoud C, Arrigo AP, Rubinsztein DC. Wyttenbach A, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2002 May 1;11(9):1137-51. doi: 10.1093/hmg/11.9.1137. Hum Mol Genet. 2002. PMID: 11978772

5

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy.

Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2003 May 1;12(9):985-94. doi: 10.1093/hmg/ddg109. Hum Mol Genet. 2003. PMID: 12700167

6

Alpha-Synuclein is degraded by both autophagy and the proteasome.

Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. J Biol Chem. 2003 Jul 4;278(27):25009-13. doi: 10.1074/jbc.M300227200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12719433 Free article.

7

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2004 Jun;36(6):585-95. doi: 10.1038/ng1362. Epub 2004 May 16. Nat Genet. 2004. PMID: 15146184

8

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

Webb JL, Ravikumar B, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. Int J Biochem Cell Biol. 2004 Dec;36(12):2541-50. doi: 10.1016/j.biocel.2004.02.003. Int J Biochem Cell Biol. 2004. PMID: 15325591

9

Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?

Ravikumar B, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Neuroreport. 2004 Nov 15;15(16):2443-5. doi: 10.1097/00001756-200411150-00001. Neuroreport. 2004. PMID: 15538170 Review.

10

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2005 Jul;37(7):771-6. doi: 10.1038/ng1591. Epub 2005 Jun 26. Nat Genet. 2005. PMID: 15980862

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