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S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.
Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Léonce S, Ferry G, Da Violante G, Bouzom F, Cattan V, Jacquet-Bescond A, Comoglio PM, Lockhart BP, Boutin JA, Cordi A, Ortuno JC, Pierré A, Hickman JA, Cruzalegui FH, Depil S. Burbridge MF, et al. Among authors: hickman ja. Mol Cancer Ther. 2013 Sep;12(9):1749-62. doi: 10.1158/1535-7163.MCT-13-0075. Epub 2013 Jun 26. Mol Cancer Ther. 2013. PMID: 23804704
Acronycine derivatives as promising antitumor agents.
Guilbaud N, Léonce S, Tillequin F, Koch M, Hickman JA, Pierré A. Guilbaud N, et al. Among authors: hickman ja. Anticancer Drugs. 2002 Jun;13(5):445-9. doi: 10.1097/00001813-200206000-00002. Anticancer Drugs. 2002. PMID: 12045455 Review.
Only a subset of Met-activated pathways are required to sustain oncogene addiction.
Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Among authors: hickman ja. Sci Signal. 2009 Dec 8;2(100):ra80. doi: 10.1126/scisignal.2000643. Sci Signal. 2009. Corrected and republished in: Sci Signal. 2009;2(102):er11. doi: 10.1126/scisignal.2102er11 PMID: 19996456 Free article. Corrected and republished.
Only a subset of Met-activated pathways are required to sustain oncogene addiction.
Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Among authors: hickman ja. Sci Signal. 2009;2(102):er11. doi: 10.1126/scisignal.2102er11. Sci Signal. 2009. PMID: 20039471
Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.
Lefoix M, Coudert G, Routier S, Pfeiffer B, Caignard DH, Hickman J, Pierré A, Golsteyn RM, Léonce S, Bossard C, Mérour JY. Lefoix M, et al. Bioorg Med Chem. 2008 May 1;16(9):5303-21. doi: 10.1016/j.bmc.2008.02.086. Epub 2008 Mar 4. Bioorg Med Chem. 2008. PMID: 18342518
211 results