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Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.

Donahue DA, Bastarache SM, Sloan RD, Wainberg MA. Donahue DA, et al. Among authors: bastarache sm. J Virol. 2013 Sep;87(17):9620-32. doi: 10.1128/JVI.01165-13. Epub 2013 Jun 26. J Virol. 2013. PMID: 23804632 Free PMC article.

Fitness impaired drug resistant HIV-1 is not compromised in cell-to-cell transmission or establishment of and reactivation from latency.

Bastarache SM, Mesplède T, Donahue DA, Sloan RD, Wainberg MA. Bastarache SM, et al. Viruses. 2014 Sep 19;6(9):3487-99. doi: 10.3390/v6093487. Viruses. 2014. PMID: 25243372 Free PMC article.

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