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REGγ deficiency promotes premature aging via the casein kinase 1 pathway.
Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X. Li L, et al. Among authors: huang s. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13. Proc Natl Acad Sci U S A. 2013. PMID: 23766372 Free PMC article.
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy.
Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. Dong S, et al. Among authors: huang s. Cell Metab. 2013 Sep 3;18(3):380-91. doi: 10.1016/j.cmet.2013.08.012. Cell Metab. 2013. PMID: 24011073 Free PMC article.
PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis.
Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z, Xiao J, Li X. Liu S, et al. Among authors: huang s. J Mol Cell Cardiol. 2014 Jul;72:28-38. doi: 10.1016/j.yjmcc.2014.02.007. Epub 2014 Feb 20. J Mol Cell Cardiol. 2014. PMID: 24560667 Free PMC article.
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.
Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X. Xu J, et al. Among authors: huang s. Nat Commun. 2016 Feb 22;7:10761. doi: 10.1038/ncomms10761. Nat Commun. 2016. PMID: 26899380 Free PMC article.
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE. Li Y, et al. Among authors: huang s. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15853-8. doi: 10.1073/pnas.2136825100. Epub 2003 Dec 10. Proc Natl Acad Sci U S A. 2003. PMID: 14668450 Free PMC article.
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.
Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y. Du Z, et al. Among authors: huang s. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17396-401. doi: 10.1073/pnas.0608607103. Epub 2006 Nov 7. Proc Natl Acad Sci U S A. 2006. PMID: 17090666 Free PMC article.
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.
Fu X, Jeselsohn R, Pereira R, Hollingsworth EF, Creighton CJ, Li F, Shea M, Nardone A, De Angelis C, Heiser LM, Anur P, Wang N, Grasso CS, Spellman PT, Griffith OL, Tsimelzon A, Gutierrez C, Huang S, Edwards DP, Trivedi MV, Rimawi MF, Lopez-Terrada D, Hilsenbeck SG, Gray JW, Brown M, Osborne CK, Schiff R. Fu X, et al. Among authors: huang s. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6600-E6609. doi: 10.1073/pnas.1612835113. Epub 2016 Oct 6. Proc Natl Acad Sci U S A. 2016. PMID: 27791031 Free PMC article.
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